适量饮酒对健康成年男性血浆TXB2,6-Keto-PGF2a及血小板聚集功能的影响

①目的　观察适量饮酒对健康成年男性的血小板聚集功能及血浆血栓素B2 (TXB2 ) ,6 酮 前列腺素F2a(6 Keto PGF2a)的影响。②方法　将 80例健康成年男性随机分成 4组 ,分别空腹饮用矿泉水、啤酒、干红葡萄酒各 2 0 0mL ,白酒 50mL加矿泉水至 2 0 0mL .于饮前及饮后 2h分别测定血小板的聚集率及解聚率 ,并采血测定血浆TXB2 ,6 Keto PGF2a.③结果　矿泉水组饮后上述指标无变化 (t=0 .0 3～ 0 .84,P >0 .0 5) ;白酒、啤酒、红葡萄酒组饮后血小板聚集率减低 (t=8.1 2～ 2 4 .39,P <0 .0 1 ) ,解聚率升高 (t=2 8.48～ 35 .2 2 ,P <0 .0 1 ) ,血浆TXB2 降低 (t=2 5 .69～ 89.83 ,P <0 .0 1 ) ,而血浆 6 Keto PGF2a升高 (t=2 1 .0 6～ 2 3 .2 9,P <0 .0 1 )。④结论　健康成年男性适量饮酒可减低其血小板聚集功能 ,降低其血浆TXB2 ,提高其血浆 6 Keto PGF2a水平

THE EFFECTS OF MODERATE ALCOHOL CONSUMPTION ON THE FUNCTIONS OF PLATELET AND PLASMA TXB2,6-Keto-PGF2a IN HEALTHY MEN

Objective\ To evaluate the effects of moderate alcohol drinking on the functions of platelet and plasma TXB 2,6 Keto PGF 2a in healthy men. \ Methods\ 80 men were divided randomly into four groups. Group 1, 200 mL of mineral water; Group 2, 200 mL of beer; Group 3, red wine, 200 mL; and Group 4, liquor 50 mL plus 150 mineral water. All were given on an empty stomach. The functions of platelet and the levels of the plasma TXB 2 and 6 Keto PGF 2a were detected before and after the detection. Results\ The above parameters did not change for Group 1 ( t=0.03-0.84,P>0 .05). For Groups 2, 3 and 4, the platelet impedance reduced ( t=8.12-24.39,P <0.01), fibrinolysis rate increased ( t=28.48-35.22, P <0.01), and plasma TXB 2 level decreased ( t=25.69-89.83, P <0.01).The level of plasma 6 Keto PGF 2a increased ( t=21.06-23.29, P <0.01). Conclusion\ Moderate alcohol consumption can improve the functions of platelet and decrease the TXB 2 levels and increase plasma 6 Keto PGF 2a .