18F-FDG和18F-FLT PET/CT在肺部良恶性肿瘤鉴别诊断中的价值

目的:分析18F-FDG(18F-脱氧葡萄糖)和18F-FLT(18F-胸腺嘧啶)两种显像剂的PET/CT检查在肺部肿瘤中的不同影像学表现,提高PET/CT在肺部良恶性肿瘤鉴别诊断中价值,从而为临床治疗方案的选择提供可靠依据。方法:收集肺肿瘤患者55例为研究对象,其中男性33例,女性22例,年龄17～82岁,28例为肺内孤立肿块,其余为2～3个肿块,肿块大小0.6～11.0cm,所有患者均行肺部18 F-FDG和18 F-FLT PET/CT检查,分析18 F-FDG和18 F-FLT标准摄取值(SUV)与肺肿瘤患者的年龄、肿块大小及病理类型等相互关系和统计学意义。结果:18 F-FDG和18 F-FLT PET/CT的SUV与肺肿瘤患者的年龄、肿块大小均无统计学差异(P>0.05),18 F-FDG PET/CT的SUV与患者的病理类型亦无统计学差异(P>0.05),而18F-FLT PET/CT的SUV与患者的病理类型有统计学差异(P<0.05)。结论:肺肿瘤患者的肿块病理类型是影响18F-FLT PET/CT的SUV的重要因素,18F-FLT PET/CT的SUV在肺部良恶性肿瘤鉴别诊断中具有重要的价值。

The vlue of 18F-FDG and 18 F-FLT PET imaging for differential diagnosing pulmonary tumour

Objective：The study aims were to investigate the diagnostic performance of dual-tracer （ 18F- fluorodexyglu- cose 18F-FDG] and 18F-fluorothymidine 18F-FL 18PET/CT in pulmonary nodules, to differentiate the malignant tissue from benign pulmonary nodules. Methods：Fifty-five patients were chose in our study, in which 28 had one pulmonary nod- ule only, others had more than two pulmonary nodules, with the diameter of pulmonary nodule from 0.6 to l1. 0 centime- ters. All the patients underwent 18F-FDG and lSF-FLT PET/CT and the maximal standardized uptaken value （SUV） of 18F-FDG or 18F-FLT were determined. PET/CT resultes were correlated with age. diameter of the nodule, and his- topathologic types. Results There were no significant differences between the SUV of lSF-FDG and age, diameter of the nodule, type of the pathologic nature of nodule of all fifty-five patients （ P 〉0.05）. Otherwise, there were significant differences between the SUV of 18F-FLT and the type of pathologic nature of nodules of all fifty-five patients （ P〉0.05）. Conclusion：The study shows that 18F-FLT PET/CT SUV can accurately differentiate segments with carcinoma from be- nign nodules.