多药耐药相关蛋白和肺耐药蛋白在胃癌中的表达

目的：检测多药耐药相关蛋白（MRP）和肺耐药蛋白（LRP）在胃癌组织中的表达，并探讨其与临床病理特征的关系。方法：采用免疫组织化学法，检测52例患者胃癌组织和30例慢性胃炎组织中MRP及LRP的表达。结果：在52例胃癌组织和30例胃炎组织中，MRP的阳性表达率分别为32.69%（17例）、10％（3例），LRP的阳性表达率分别为63.46%（33例）、33.33%（10例），差异均有显著性意义（P＜0.05）。MRP的表达与胃癌病理分期和分化程度相关（P＜0.05）；LRP的表达与淋巴结转移相关（P＜0.05）。两蛋白在胃癌中的表达呈正相关（P＜0.05）。结论：MRP和LRP在胃癌组织中均有较高的表达，两者均可能是胃癌原发性多药耐药（MDR）的一种重要机制，且两者可能具有协同作用；临床上检测该两蛋白的表达，有利于为胃癌患者制定更加合理的综合治疗方案。

Expression of Multidrug-Resistance Associated Protein and Lung Resistance Protein in Human Gastric Carcinomas and Its Clinical Significance

Objective: To investigate the expression of multidrug resistance associated protein (MRP) and lung resistance protein (LRP) in human gastric carcinomas and its clinical significance. Methods: Paraffin embedded specimens of 52 cases of primary gastric carcinomas and 30 cases of gastritis were examined with immunohistochemistry staining (SABC). Results: Among the 52 cases of gastric cancers and the 30 cases of gastritis specimens, the positive staining for MRP were 17(32 69%) and 3(10%) respectively, and those for LRP were 33(63.46%) and 10(33.33%) respectively, and there were significant differences between the 2 groups for both proteins (P<0 05). Positive staining of MRP was correlated with cell differentiation and pathologic stage (P<0 05), while LRP positive staining was correlated with lymph nodes metastasis (P<0 05). And the expression of the two proteins in gastric cancers was correlative (P<0 05). Conclusion: Positive expression of MRP and LRP are both high in gastric cancers, and both of them may be one of the important mechanisms of intrinsic multidrug resistance and play a cooperative part in gastric cancers.