| 阿托伐他汀对2型糖尿病血管内皮功能的影响 |
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| 引用本文： | 吴俊兰.阿托伐他汀对2型糖尿病血管内皮功能的影响[J].中国临床实用医学,2010,4(1):79-81. |
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| 作者姓名： | 吴俊兰 |
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| 作者单位： | 甘肃省兰州市第二人民医院心内科,730060 |
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| 摘 要： | 目的研究阿托伐他汀对2型糖尿病血管内皮功能及血脂的影响。方法分别检测180例2型糖尿病（rr2DM）患者的血糖、血压、血脂、一氧化氮（NO）、血管内皮素（ET）、6-酮-前列腺素（PGF1a）。同时采用高分辨超声检测内皮细胞依赖性舒张功能（FMD％）、内皮细胞非依赖性舒张功能（GTN％）。结果阿托伐他汀治疗后NO、PGF1a明显增加（P〈0．05），ET明显降低（P〈0．05）；FMD％明显改善（P〈0．05），GTN％无明显变化（P〉0．05）。结论阿托伐他汀通过降低低密度脂蛋白、提高高密度脂蛋白、升高NO、PGF1a,降低ET水平等途径实现对T2DM患者内皮功能保护作用，减少内皮功能紊乱（ECD）相关性疾病的发生发展。
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| 关 键 词： | 阿托伐他汀 2型糖尿病 血管内皮功能 |
Effect of atravastain on function of vascular endothelium in patients with T2DM |
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| WU Jun-lan.Effect of atravastain on function of vascular endothelium in patients with T2DM[J].China Clinical Practical Medicine,2010,4(1):79-81. |
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| Authors: | WU Jun-lan |
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| Institution: | WU Jun-lan.( The Second People＇ s Hospital of Lanzhou City, Gansu Lanzhou , Gansu 730060, China) |
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| Abstract: | Objective To study the effect of atravastain on vascular endothelium in patients with T2 DM. Methods 180 cases of T2 DM were detected in patients with blood Sugar、 Blood pressure、 Blood lipids、NO、ET、PGF1a. At the same time we used high differentiate ultrasonic to dect FMD％ 、GTN％. Results Patients treated with atravastain whose NO、 PGF1a indreased obviously, ET decreased significantly, FMD％ improved, GTN％ no distint change. Conclusion Atravastain by reducing LDL、ET、HDL、NO 、PGF1a means to achieve the protection of vascular endothelium in patients with T2DM, reduce the incidence of diseases associate with ECD. |
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| Keywords: | Atravastain T2 DM Function of vascular endothelium |
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