探讨不同病因的中晚期慢性肾脏病患者临床特点及意义

目的 探讨慢性肾脏病(CKD)的病因以及不同病因中晚期CKD患者的临床特点.方法 收集2007-03～2010-09间,我院肾内科住院CKD 235例患者临床和实验室检查的病历资料,分析CKD的病因和不同病因的中晚期CKD患者(CKD IV～V)临床特点.结果 235例CKD患者中,慢性肾炎79例(36.2%)、糖尿病...

Clinical Features of Chronic Kidney Disease with Different Etiology at Middle and Advanced Stage and the Analysis of Its Potential Significance

Objective To discuss the etiology of chronic kidney disease(CKD) and the clinical characteristic of CKD patients with different pathogenesis. Methods A total of 235 in-patients with CKD at the division of nephrology of first affiliated hospital of medical college of Shantou University were enrolled between March 2007 to September 2010,and the clinical and laboratory parameters of the patients were collected to analyze the etiology of CKD and the clinical features of CKD patients at intermediate and advanced stage(CKD IV~V). Results Among the 235 CKD patients,there were 79 cases with chronic nephritis(36.2%),55 cases with diabetic nephropathy(24.7%),37 cases with hypertension nephropathy(24.3%),9 cases with lupus nephritis(3.8%),8 cases with polycystic kidney(3.4%),5 cases with gouty nephropathy(2.1%),5 cases with obstructive nephropathy(2.1%) and 8 cases of the other causes(3.4%).At CKD(IV~V) stage,serum albumin was lowest and blood glucose was highest in patients with diabetic nephropathy.While age,aortic dimension(AO) and the incidence of valvular calcification were lowest in patients with chronic nephritis;but the incidence of gouty arthritis was highest in patients with hypertension nephropathy.Compared with chronic nephritis,blood pressure of patients with diabetic nephropathy was decreased and the incidence of interventricular septum hypertrophy and cerebral infarction were increased.When comparison with hypertension nephropathy,a increased incidence of pericardial effusion and a deceased incidence of left ventricular diastolic dysfunction in patients with chronic nephritis were also observed. Conclusion Chronic nephritis,diabetic nephropathy and hypertension nephropathy were the mainly causes of CKD.Patients with diabetic nephropathy were inclined to malnutrition and the cardiovascular complication was more severity in patients with hypertension nephropathy and diabetic nephropathy.