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| N—酰化苄基四氢异喹啉类化合物的合成及其抗血小板聚集活性 | |
| 引用本文： | N—酰化苄基四氢异喹啉类化合物的合成及其抗血小板聚集活性[J]. 中国药科大学学报, 1997, (5): 3+6-7. |
| 作者姓名： | 高林东 孔荣祖 |
| 作者单位： | 华东理工大学药物化工研究所(高林东)，中国药科大学药物化学教研室(孔荣祖) |
| 摘 要： | 合成了１４个Ｎ－酰化苄基四氢异喹啉化合物，并选择其中１０个化合物做了抗血小板聚集作用的体外试验，结果发现多数均具有一定的活性，为今后该类化合物的研究提供了参考数据。 |
| 关 键 词： | N-酰化四氢异喹啉 抗血小板聚集 合成 |
Synthesis and Antiplatelet Aggregation of N Acylated Tetrahydrobenzylisoquinoline |
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| Synthesis and Antiplatelet Aggregation of N Acylated Tetrahydrobenzylisoquinoline[J]. Journal of China Pharmaceutical University, 1997, (5): 3+6-7. | |
| Authors: | Gao Lindong Kong Rongzu Institute of Pharmaceuticals Pesticides East China University of Science Technology Shanghai |
| Affiliation: | Gao Lindong,Kong Rongzu 1 Institute of Pharmaceuticals and Pesticides,East China University of Science and Technology,Shanghai 200237, 1Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009 |
| Abstract: | Fourteen N acylated tetrahydrobenzylisoquinoline derivatives were designed and synthesized of which 13 were not reported previously. The preliminary pharmacological tests showed that most compounds exhibited various degrees of antiplatelet aggregation in vitro . |
| Keywords: | N Acyltetrahydroisoquinoline Antiplatelet aggregation Synthesis |
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