阿维菌素原药急性中毒对大鼠血清生化指标的影响

目的了解阿维菌素急性经口LD50和中毒症状及急性中毒后对某些血清生化指标的影响。方法根据《农药登记毒理学试验方法》采用霍恩氏法对大鼠进行急性经口毒性试验和毒性评价;对各组大鼠进行血清中TP、ALB、AST;ALT、BUN、Crea水平的测定,并进行统计分析。结果阿维菌素原药急性经口LD50为43.0mg/kg,为高毒。AST、ALT、BUN水平对照组和阿维菌素各组间差异无统计学意义(P0.05)。TP、ALB、Crea水平对照组与实验组间差异有统计学意义(P0.05)。结论阿维菌素急性经口为高毒,急性中毒后血清中的TP、ALB、Crea水平有显著增高。

Effect of Avermectin TC Induced Acute Poisoning on Serum Biochemical Index of Rats

[ Objective ] To understand the acute oral toxicity of avermectin with LD50 and poisoning symptom, and observe the serum biochemical index change after acute avermectin poisoning. [ Methods] According to ＂Pesticide Registration Toxicological Test Methods＂, Horn＇s method was adopted to conduct acute oral toxicity testing and evaluation; the serum levels of TP, ALB, AST, ALT, BUN, CREA were determined in different rat groups; the results were analyzed statistically. [ Results ] Avermectin acute oral LD50 was 43.0 mg/kg, which defined as hypertoxic. The differences of AST, ALT, BUN levels between control group and avermectin group were not significant （ P 〉 0.05 } ; while that of rIp, ALB, CREA levels were significant （ P 〈 0.05 }. [ Conclusion ] Avermectin acute oral toxicity is hypertoxic; serum TP, ALB and CREA levels significantly increase after being acute poisoned.