Human bone marrow-derived mesenchymal stem cells produced TGFbeta contributes to progression and metastasis of prostate cancer |
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| Authors: | Ye Huamao Cheng Jiwen Tang Yuanjie Liu Zhiyong Xu Chuanliang Liu Yan Sun Yinghao |
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| Affiliation: | Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China. |
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| Abstract: | Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. The expression of MMP-2 and MMP-9 in PC-3 was upregulated by conditional medium of hMSCs. In addition, blocking tumor transformation factor beta (TGFβ) blunted the pro-oncogenic function of hMSCs. These results suggest that hMSCs may play a pro-oncogenic role in the growth of human prostate caner by producing TGFβ. |
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