糖化血红蛋白与血糖的相关性分析及其对糖尿病诊断敏感性探讨

目的：行糖化血红蛋白（HbA1c）与空腹血糖（FPG）、餐后2h血糖（2hPG）相关性分析,探讨其在糖尿病（DM）诊断中的价值。方法：同时测定150例门诊就诊者FPG、HbA1c、2hPG,将HbA1c按不同切点分组计算各自对DM诊断的灵敏性及特异性。结果：150例就诊患者中确诊109例DM患者,其FPG、HbA1c、2hPG与非DM患者组比较显著增高（P〈0.01）;DM组中,HbA1c与FPG、2hPG正相关;HbA1c对DM诊断的灵敏性较FPG好;HbA1c对DM诊断的最佳切点为6.5%。结论：FBG的波动性较大,2hPG检查繁琐,HbA1c测定对DM的诊断有一定价值及优势。

To analysis the correlation of glycated hemoglobin and blood glucose and investigate the sensitivity of glycated hemoglobin in diagnosis of diabetes

Objective：To analyze the correlation among glycated hemoglobin（HbA1c） and fasting plasma glucose（FPG） and postprandial 2 h blood glucose（2 h PG）,then exploring the value of HbA1c in diagnosis of diabetes.Methods：To determine the FPG,2 h PG,HbA1c for 150 cases of outpatients.Then the patients were divided into 3 groups by different hemoglobin concentration,calculating the sensitivity and specificity for diagnosis of diabetes in 3 groups severally.Results：109 cases were diagnosed DM.FPG,HbA1c and 2 h PG in DM patients were significantly higher（P〈0.01） comparing with the non-DM patients.HbA1c had positive correlation with FPG and 2 h PG.The sensitivity of HbA1c was better than the FPG in diagnosis of diabetes and the best concentration was 6.5%.Conclusion：The FBG is fluctuant and 2 h PG is cumbersome in detecting,so there is value and advantages for HbA1c in diagnosis of diabetes.