低分子肝素治疗老年急性心肌梗死的临床观察

目的:观察低分子肝素(速避凝)在老年急性心肌梗死抗凝治疗中的价值。方法:将56例丧失溶栓机会的老年急性心肌梗死患者随机分为两组:对照组25例,按急性心肌梗死常规治疗加口服肠溶阿司匹林300mg,每日1次,7d为一疗程;治疗组31例,除按对照组方法处理外,给予低分子肝素0.4ml腹壁脐旁皮下注射,每日2次,7d为一疗程。观察心肌梗死30d内两组心脑事件(梗死后心绞痛、再梗死、心性猝死、脑卒中)发生情况及疗程结束后胸痛或胸闷缓解情况和心电图改善情况。结果:治疗组心脑事件发生率较对照组明显减少(P<0.05),胸痛或胸闷缓解情况和心电图改善率较对照组明显提高(P<0.05)。结论:低分子肝素在老年急性心肌梗死治疗中能明显减少心脑事件发生率,在缓解胸痛或胸闷方面和心电图改善方面有显著疗效。

Clinical Observation of Fraxiparine in the Treating Senile Acute Myocardial Infarction

Objective To observe the effectiveness of low-molecular weight heparins(Fraxiparine)in the anticoagulant treating senile patients with acute myocardial infarction.Methods 56 cases of senile acute myocardial infarction who have no chance for thrombolysis were randomly divided into two groups:control group(n=25),normal treatment and oralenteric-coated aspirin were given for 7 days(300 mg,once daily);treating group(n=31),except Fraxiparine was given subcutaneously for 7 days(0.4 ml,twice daily),the rest is same as that of control.The occurrence of maior cardiocerebral events(angina pectoris after myocaraial infarction,recurred infarct,sudden deathdue ti heart failure,cerebral apoplexy)within 30 days after myocardial infarction,and the remission of chest pain and the changing of electrocardiogram(ECG)after ther apy were compared between the two groups.Results The incidence of cardiocerebraleventswas decreased significantly in treating group(P<0.05).The remission rate of chest pain and the amelioration rate of ECG were significantly higher in treatment group than control(P<0.05).Conclusions Fraxiparine can effectively decrease the incidence of cardiocerebralevents and incrase the remission rate of chestp pain and the amelioration rate of ECG.