| 中药关键质量属性快速评价：近红外化学成像可视化技术 |
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| 引用本文： | 周璐薇,吴志生,史新元,裴艳玲,乔延江.中药关键质量属性快速评价：近红外化学成像可视化技术[J].世界科学技术-中医药现代化,2014,16(12):2568-2574. |
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| 作者姓名： | 周璐薇 吴志生 史新元 裴艳玲 乔延江 |
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| 作者单位： | 北京中医药大学中药学院 北京 100102；国家中医药管理局中药信息工程重点研究室 北京 100102;北京中医药大学中药学院 北京 100102；中国中医科学院道地药材国家重点实验室培育基地 北京 100700;北京中医药大学中药学院 北京 100102；国家中医药管理局中药信息工程重点研究室 北京 100102;北京中医药大学中药学院 北京 100102；国家中医药管理局中药信息工程重点研究室 北京 100102;北京中医药大学中药学院 北京 100102；国家中医药管理局中药信息工程重点研究室 北京 100102 |
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| 基金项目： | 国家自然科学基金委青年基金项目（81303218）：多源信息融合的中药近红外模型适用性评价方法研究，负责人：吴志生；国家中医药管理局行业专项（201407003）：NIR模型群的金银花与山银花质量快速可靠性评价研究，负责人：吴志生。 |
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| 摘 要： | 近红外化学成像是一门新兴的中药关键质量属性快速分析技术。它将传统近红外光谱技术与化学成像技术相结合。本文简要介绍了近红外化学成像可视化的核心部件；重点阐述高维数据可靠性获取、转化、分析及应用；综述了近红外化学成像在制药领域的应用研究，分析了近红外成像技术应用于中药质量控制领域所面临的机遇与挑战。
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| 关 键 词： | 近红外化学成像 过程分析技术 中药关键质量属性 可视化 图像分析 |
| 收稿时间： | 2014/10/31 0:00:00 |
| 修稿时间： | 2014/12/4 0:00:00 |
Rapid Assessment of Critical Quality Attributes of Chinese Materia Medica: Visualization Technology of Near Infrared Chemical Imaging |
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| Zhou Luwei,Wu Zhisheng,Shi Xinyuan,Pei Yanling and Qiao Yanjiang.Rapid Assessment of Critical Quality Attributes of Chinese Materia Medica: Visualization Technology of Near Infrared Chemical Imaging[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2014,16(12):2568-2574. |
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| Authors: | Zhou Luwei Wu Zhisheng Shi Xinyuan Pei Yanling and Qiao Yanjiang |
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| Institution: | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China; Key Laboratory of Traditional Chinese Medicine-information Engineering of State Administration of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China; State Key Laboratory Breeding Base of Dao-di Herbs, China Academy of Chinese Medical Sciences, Beijing 100700, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China; Key Laboratory of Traditional Chinese Medicine-information Engineering of State Administration of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China; Key Laboratory of Traditional Chinese Medicine-information Engineering of State Administration of Traditional Chinese Medicine, Beijing 100102, China;School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China; Key Laboratory of Traditional Chinese Medicine-information Engineering of State Administration of Traditional Chinese Medicine, Beijing 100102, China |
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| Abstract: | Near infrared chemical imaging (NIR-CI) is an emerging technology for rapidly analyzing the critical quality attribute of Chinese materia medica (CMM). It integrates NIR spectroscopy with chemical imaging. In this paper, it provided a systematic introduction to NIR-CI, such as the core part of instrument, the reliability, transformation, analysis and application of high-dimensional data acquisition. In addition, current studies of NIR-CI application in pharmaceutical field were analyzed. Finally, future opportunities and challenges of NIR-CI applications in the quality control of CMM preparation were prospected. |
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| Keywords: | Near-infrared chemical imaging process analysis technology critical quality attributes of Chinese materia medica visualization image analysis |
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