Multiple metabolic pathways for the mutagenic activation of 3-nitrobenzo[a]pyrene |
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| Authors: | Chou, Ming W. Heflich, Robert H. Fu, Peter P. |
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| Affiliation: | National Center for Toxicological Research Jefferson, AR 72079, USA |
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| Abstract: | Rat liver microsomal metabolism of the potent mutagen 3-nitrobenzo[a]pyrene(3-nitro-BaP) under aerobic conditions yielded 3-nitro-BaP trans-7,8-dihydrodioland 3-nitro-BaP trans-9,10-dihydrodiol, and under anaerobicconditions produced 3-amino-BaP. All of these metabolites werehighly mutagenic in the Salmonella typhimurium reversion assayboth with and without exogenous metabolic activation (S9). Noneof the in vitro metabolic pathways led to detoxification of3-nitro-BaP. |
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