Sida rhomboidea.Roxb leaf extract ameliorates gentamicin induced nephrotoxicity and renal dysfunction in rats |
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Authors: | Menaka C Thounaojam AV Ramachandran |
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Institution: | Division of Phytotherapeutics and Metabolic Endocrinology, Department of Zoology, The M. S. University of Baroda, Vadodara 390 002, Gujarat, India |
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Abstract: | Ethnopharmacological relevanceSida rhomboidea.Roxb (SR) known as “Mahabala” in Ayurveda and marketed as “Shahadeyi” is used in ethnomedicine to treat ailments such as dysuria and urinary disorders.Aim of the studyTo evaluate nephroprotective potential of SR against gentamicin (GM) induced nephrotoxicity and renal dysfunction.Materials and methodsNephrotoxicity was induced in rats with GM (100 mg/kg bodyweight (i.p.) for 8 days) and were treated with SR extract (200 and 400 mg/kg bodyweight (p.o.) for 8 days) or 0.5% carboxymethyl cellulose (vehicle). Plasma and urine urea and creatinine, renal enzymatic and non-enzymatic antioxidants along with lipid peroxidation were evaluated in various experimental groups.ResultsGM treatment induced significant elevation (p < 0.05) in plasma and urine urea, creatinine, renal lipid peroxidation along with significant decrement (p < 0.05) in renal enzymatic and non-enzymatic antioxidants. SR treatment to GM treated rats (GM + SR) recorded significant decrement (p < 0.05) in plasma and urine urea and creatinine, renal lipid peroxidation along with significant increment (p < 0.05) in renal enzymatic and non-enzymatic antioxidants.ConclusionSR leaf extract ameliorates GM induced nephrotoxicity and renal dysfunction and thus validates its ethnomedicinal use. |
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Keywords: | Gentamicin Nephrotoxicity Renal dysfunction Sida rhomboidea Roxb |
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