| 细胞紧密连接的结构组成及其调控的研究进展 |
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| 引用本文： | 马怡然,尚德淑,方文刚,陈誉华. 细胞紧密连接的结构组成及其调控的研究进展[J]. 解剖科学进展, 2010, 16(1): 71-74 |
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| 作者姓名： | 马怡然 尚德淑 方文刚 陈誉华 |
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| 作者单位： | 中国医科大学基础医学院卫生部细胞生物学重点实验室发育生物学教研室,辽宁沈阳110001;中国医科大学附属第一医院输血科,辽宁沈阳110001;中国医科大学基础医学院卫生部细胞生物学重点实验室发育生物学教研室,辽宁沈阳,110001 |
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| 基金项目： | 教育部跨世纪人才基金(2002教技函48号);;教育部博士点基金(20040159002) |
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| 摘 要： | 紧密连接(tight junction)位于相邻细胞间隙的顶端侧面,对于维持表皮和内皮细胞的选择渗透性屏障功能是非常关键的。紧密连接有两个主要功能:渗透性调节功能、维持细胞极性。本文综述了最新研究的紧密连接的蛋白质组成、紧密连接组装的信号调节、组成蛋白间的相互作用调控机制以及在生命活动中意义,为寻找某些疾病的治疗方案提供一定的理论基础。
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| 关 键 词： | 细胞紧密连接 结构组成 调控 蛋白质组成 信号调节 细胞间隙 屏障功能 内皮细胞 |
The progress of cell tight junction structure and regulation |
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| MA Yi-ran,,SHANG De-shu ,FANG Wen-gang ,CHEN Yu-hua. The progress of cell tight junction structure and regulation[J]. Progress of Anatomical Sciences, 2010, 16(1): 71-74 |
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| Authors: | MA Yi-ran SHANG De-shu FANG Wen-gang CHEN Yu-hua |
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| Affiliation: | 1.Department of Developmental Biology;Key Laboratory of Cell Biology;Ministry of Public Health;2.Department of Transfusion;the First Affiliated Hospital;China Medical University;Shenyang 110001 China |
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| Abstract: | Tight junction is located in the top side of the gap of adjacent cells, which is critical for the maintenance of the epidermis and the choice of endothelial cell permeability barrier function. There are two main functions of tight junction: regulatory function of permeability and the maintenance of cell polarity. This paper reviews the latest research of the protein composition of tight junctions, signal conditioning of the tight junctions assembly, interactions and regulatory mechanisms of composed protein... |
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