| ras-丝裂原浯化蛋白质激酶通路与肿瘤靶向治疗 |
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| 引用本文： | 于虹,马秀梅. ras-丝裂原浯化蛋白质激酶通路与肿瘤靶向治疗[J]. 国际肿瘤学杂志, 2009, 36(7). DOI: 10.3760/cma.j.issn.1673-422X.2009.07.001 |
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| 作者姓名： | 于虹 马秀梅 |
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| 作者单位： | 内蒙古医学院研究生院2007级研究生班,010059;内蒙古医学院附属医院病理科 |
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| 基金项目： | 国家自然科学基金,博士科研启动金资助项目,国家春晖计划基金 |
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| 摘 要： | ras-丝裂原活化蛋白质激酶通路细胞信号转导网调节细胞的分化、细胞骨架的构建、蛋白质的转运等许多生理过程.近年来在肿瘤治疗中得到了进一步的重视与应用,很多临床研究将重点放在其抑制制剂通路上,如Raf激酶抑制剂、丝裂原活化蛋白激酶(MAPK)激酶(MEK)抑制剂、Src激酶抑制剂通路等.
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| 关 键 词： | 信号传导 丝裂原激活蛋白激酶类 靶向治疗 |
The ras-mitogen activeted protein kinase pathway and target for cancer therapy |
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| YU Hong,MA Xiu-mei. The ras-mitogen activeted protein kinase pathway and target for cancer therapy[J]. Journal of International Oncology, 2009, 36(7). DOI: 10.3760/cma.j.issn.1673-422X.2009.07.001 |
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| Authors: | YU Hong MA Xiu-mei |
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| Abstract: | The ras-mitogen activeted protein kinase pathway is responsible for regulation of many cel-lular processes, including differentiation, cytoskeletal organization, and protein trafficking. Much attention has been paid to them and their role in cancer therapy recently, and its inhibitor pathways are applied to clinical tes-ting, such as, Raf kinse inhibitors, MEK inhibitor, Src kinase inhibitor. |
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| Keywords: | Signal transduction Mitogen-activated protein kinases Target for therapy |
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