IL-17和IL-6在特发性肺纤维化患者中的表达及意义

目的探讨特发性肺纤维化患者支气管肺泡灌洗液和血清中白细胞介素-17(IL-17)和白细胞介素-6(IL-6)水平的变化及临床意义。方法选择:31例特发性肺纤维化患者(病例组)和14例健康就诊者(对照组)为研究对象,采用ELISA法检测两组组BALF和外周血中IL-17和IL-6的水平,分析病例组患者IL-17和IL-6水平与其肺功能的关系。结果 IPF组患者血清和BALF中IL-6水平为均明显高于对照组水平(P0.01);IPF组患者血清和BALF中IL-17水平均明显高于对照组水平(P0.01);IPF组患者血清和BALF患者的IL-6和IL-17水平与FVC、FEV1、FEV1∕FVC和DLco水平均呈现明显的负相关性(P均0.01)。结论 IL-17和IL-6可能在IPF的发病过程中发挥一定作用,并有可能作为判断IPF病情严重程度的一项指标。

Expression and significance of interlenkin-17 and interlenkin-6 in serum and bronchoalveolar lavage fluid of patient with idiopathic pulmonary fibrosis

Objective To study the significance of interleukin-17 ( IL-17 ) and interlenkin-6 ( IL-6 ) in pe-ripheral blood and bronchoalveolar lavage fluid ( BALF ) from patients with idiopathic pulmonary fibrosis ( IPF ) . Methods The levels of IL-17 and IL-6 were determined with ELISA in serum and BALF of 31 patients with IPF ( the case group) and 14 subjects without interstitial lung diseases ( the control group) . The relationship of IL-17 and IL-6 levels with lung function was analyzed. Results The level of IL-6 in BALF of patients with IPF was significant-ly higher than that in the control group (P<0. 01), and it was higher than that in serum (P<0. 01). The level of IL-17 in BALF of patients with IPF was significantly higher than that in the control group ( P<0. 01 ) , and it was higher than that in serum (P<0. 01). The levels of IL-6 and IL-17 in serum and BALF of patient with IPF showed a strong positive correlation with pulmonary function test (P<0. 01). Conclusion The levels of IL-17 and IL-6 may play an important role in the pathogenesis of IPF and be a potential marker of IPF activity.