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| 维甲酸诱导失分化型甲状腺癌的观察 | |
| 引用本文： | 袁耿彪,匡安仁,范群,郭兴,王全林,管昌田,于南. 维甲酸诱导失分化型甲状腺癌的观察[J]. 中华内分泌代谢杂志, 2008, 24(3) |
| 作者姓名： | 袁耿彪 匡安仁 范群 郭兴 王全林 管昌田 于南 |
| 作者单位： | 四川大学华西医院核医学科,第一作者现在重庆医科大学附属第二医院核医学科,成都,610041 |
| 基金项目： | 教育部高等学校博士学科点专项科研基金 |
| 摘 要： | 应用全反式维甲酸(ATRA)诱导失分化型甲状腺癌(dDTC)患者,5例患者(5/9,55.6%)ATRA诱导有效;5例患者(5/8,62.5%)131I治疗获益.3例患者(3/12,25.O%)因神经系统的不良反应,不能耐受而放弃ATRA诱导.ATRA是诱导dDTC分化的有效方法,可以提高dDTC病灶的摄碘能力,但使用中应关注ATRA的不良反应. |
| 关 键 词： | 全反式维甲酸 失分化型甲状腺癌 诱导 不良反应 |
Investigation of retinoic acid in dedifferentiated thyroid carcinoma induction |
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| YUAN Geng-biao,KUANG An-ren,FAN Qun,GUO Xing,WANG Quan-lin,GUAN Chang-tian,YU Nan. Investigation of retinoic acid in dedifferentiated thyroid carcinoma induction[J]. Chinese Journal of Endocrinology and Metabolism, 2008, 24(3) | |
| Authors: | YUAN Geng-biao KUANG An-ren FAN Qun GUO Xing WANG Quan-lin GUAN Chang-tian YU Nan |
| Abstract: | The patients with dedifferentiated thyroid carcinoma were induced by all-trans retinoic acid (ATRA). The treatment was effective in 5 patients (5/9,55.6%), and 5 patients were benefited from following 131 I treatment(5/8, 62.5% ). Three patients(3/12,25.0% ) quitted because of neurological side-effects. It is efficacious to apply ATRA to induce dedifferentiated thyroid carcinoma and improve radio-iodine uptake and acquire benefit for patients, but clinic application of ATRA must be cautious. |
| Keywords: | All trans retinoic acid Dedifferentiated thyroid carcinoma Induction Toxicity |
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