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| 青蒿化学成分及药理作用研究进展 | |
| 引用本文： | 李海波,秦大鹏,葛雯,王振中,曹亮,肖伟,于洋,姚新生. 青蒿化学成分及药理作用研究进展[J]. 中草药, 2019, 50(14): 3461-3470 |
| 作者姓名： | 李海波 秦大鹏 葛雯 王振中 曹亮 肖伟 于洋 姚新生 |
| 作者单位： | 江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;中药提取精制新技术重点研究室, 江苏 连云港 222047,暨南大学中药及天然药物研究所, 广东 广州 510632,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;中药提取精制新技术重点研究室, 江苏 连云港 222047;浙江医药高等专科学校, 浙江 宁波 315100,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;中药提取精制新技术重点研究室, 江苏 连云港 222047,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;中药提取精制新技术重点研究室, 江苏 连云港 222047,江苏康缘药业股份有限公司, 江苏 连云港 222001;中药制药过程新技术国家重点实验室, 江苏 连云港 222001;中药提取精制新技术重点研究室, 江苏 连云港 222047,暨南大学中药及天然药物研究所, 广东 广州 510632,暨南大学中药及天然药物研究所, 广东 广州 510632 |
| 基金项目： | 国家自然科学基金重点项目（81630097）；热毒宁注射液标准化建设（ZYBZH-C-JS-31）；桂枝茯苓胶囊标准化建设（ZYBZH-C-JS-28） |
| 摘 要： | 青蒿为常用中药,主要含有倍半萜、二萜、黄酮、苯丙酸、香豆素、黄酮和挥发油等多种类型化学成分,具有抗疟疾、抗肿瘤、抑菌杀虫、解热抗炎、免疫调节等药理活性。显著的抗疟活性使青蒿较早就用于疟疾的治疗。对近年来有关青蒿的化学成分及药理活性进行综述,以期为其进一步的开发与合理利用提供参考。 |
| 关 键 词： | 青蒿 倍半萜类 黄酮类 抗疟疾 解热 抗炎 |
| 收稿时间： | 2019-03-11 |
Research progress on chemical constituents of Artemisia annua and its pharmacological activities |
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| LI Hai-bo,QIN Da-peng,GE Wen,WANG Zhen-zhong,CAO Liang,XIAO Wei,YU Yang and YAO Xin-sheng. Research progress on chemical constituents of Artemisia annua and its pharmacological activities[J]. Chinese Traditional and Herbal Drugs, 2019, 50(14): 3461-3470 | |
| Authors: | LI Hai-bo QIN Da-peng GE Wen WANG Zhen-zhong CAO Liang XIAO Wei YU Yang YAO Xin-sheng |
| Affiliation: | Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Key Laboratory for New Technique Research of TCM Extraction and Purification, Lianyungang 222047, China,Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China,Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Key Laboratory for New Technique Research of TCM Extraction and Purification, Lianyungang 222047, China;Zhejiang Pharmaceutical College, Ningbo 315100, China,Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Key Laboratory for New Technique Research of TCM Extraction and Purification, Lianyungang 222047, China,Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Key Laboratory for New Technique Research of TCM Extraction and Purification, Lianyungang 222047, China,Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China;Key Laboratory for New Technique Research of TCM Extraction and Purification, Lianyungang 222047, China,Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China and Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China |
| Abstract: | As a commonly used Chinese materia medica, Artemisia annua mainly contains sesquiterpenoids, diterpenes, phenylpropionic acids, coumarins, flavonoids, volatile oil, and other chemical compositions. Its pharmacological activities are anti-malaria, anti-tumor, anti-microbial, anti-parasitic, antipyretic, anti-inflammatory, immunoregulation and so on. The significantly anti-malarial activity has led to its earlier use in the treatment of malaria. In this paper, the chemical constituents and pharmacological activities of A. annua in recent years are reviewed in order to provide a reference for the further development and rational utilization of this plant resource. |
| Keywords: | Artemisia annua L. sesquiterpenoids flavonoids antimalaria activity antipyretic effect anti-inflammatory activity |
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