| 鸡胚绒毛膜尿囊膜血管试验用于评价化妆品配方眼刺激性质量标准的建立与评价 |
| |
| 引用本文： | 何立成,刘璐,沈琴,钱飞飞,朱社敏,张劲松,匡荣. 鸡胚绒毛膜尿囊膜血管试验用于评价化妆品配方眼刺激性质量标准的建立与评价[J]. 中国现代应用药学, 2019, 36(22): 2780-2783 |
| |
| 作者姓名： | 何立成 刘璐 沈琴 钱飞飞 朱社敏 张劲松 匡荣 |
| |
| 作者单位： | 浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,绍兴市现代医药公共服务中心, 浙江绍兴 312073,绍兴市现代医药公共服务中心, 浙江绍兴 312073,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052,浙江省食品药品检验研究院, 杭州 310052 |
| |
| 基金项目： | 浙江省食品药品监管系统科技计划项目（2018019） |
| |
| 摘 要： | 目的 建立鸡胚绒毛膜尿囊膜血管试验用于评价化妆品配方眼刺激性的标准。方法 通过对鸡胚绒毛膜尿囊膜血管试验原有判定方法的改进，建立针对化妆品配方眼刺激性评价的质量标准，以此对10种不同类型共20批次的化妆品配方进行眼刺激性评价，并将结果与家兔法相比较，验证质量标准的可行性。结果 20批次的化妆品配方鸡胚绒毛膜尿囊膜血管试验结果与家兔法相比一致率为85%（17/20）。结论 所建立的标准可用于化妆品配方眼刺激性评价。
|
| 关 键 词： | 鸡胚绒毛膜尿囊膜血管试验 化妆品配方 眼刺激性 |
| 收稿时间： | 2019-01-11 |
Establishment and Evaluation of Eye Irritation Standard in Cosmetic Formula by Using Chorioallantoic Membrane Vascular Assay |
| |
| HE Licheng,LIU Lu,SHEN Qin,QIAN Feifei,ZHU Shemin,ZHANG Jinsong and KUANG Rong. Establishment and Evaluation of Eye Irritation Standard in Cosmetic Formula by Using Chorioallantoic Membrane Vascular Assay[J]. The Chinese Journal of Modern Applied Pharmacy, 2019, 36(22): 2780-2783 |
| |
| Authors: | HE Licheng LIU Lu SHEN Qin QIAN Feifei ZHU Shemin ZHANG Jinsong KUANG Rong |
| |
| Affiliation: | Zhejiang Institute of Food and Drug Control, Hangzhou 310052, China,Zhejiang Institute of Food and Drug Control, Hangzhou 310052, China,Shaoxing Modern Medicine Public Service Center, Shaoxing 312073, China,Shaoxing Modern Medicine Public Service Center, Shaoxing 312073, China,Zhejiang Institute of Food and Drug Control, Hangzhou 310052, China,Zhejiang Institute of Food and Drug Control, Hangzhou 310052, China and Zhejiang Institute of Food and Drug Control, Hangzhou 310052, China |
| |
| Abstract: | OBJECTIVE To establish eye irritation test standards for evaluating cosmetics by using chorioallantoic membrane vascular assay. METHODS The chorioallantoic membrane vascular assay(CAMVA) standard method of eye irritation by improving the evaluation system was established, and 20 batches of cosmetics of ten different types were evaluated. Compared the results with the Draize test and verified the feasibility of the CAMVA standard method. RESULTS The classification consistency of 20 batches of cosmetics on CAMVA and Draize test was 85% (17/20). CONCLUSION Established standards can be used in eye irritation test of cosmetics. |
| |
| Keywords: | chorioallantoic membrane vascular assay cosmetic eye irritation |
|
| 点击此处可从《中国现代应用药学》浏览原始摘要信息 |
|
点击此处可从《中国现代应用药学》下载全文 |
|
