| 基于网络药理学的疏风解毒胶囊配伍合理性研究 |
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| 引用本文： | 韩彦琪,朱强,董亚楠,许浚,龚苏晓,张洪兵,潘君,张铁军,刘昌孝. 基于网络药理学的疏风解毒胶囊配伍合理性研究[J]. 中草药, 2019, 50(15): 3547-3554 |
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| 作者姓名： | 韩彦琪 朱强 董亚楠 许浚 龚苏晓 张洪兵 潘君 张铁军 刘昌孝 |
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| 作者单位： | 天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,安徽济人药业有限公司, 安徽 亳州 236800,银川市中医医院, 宁夏 银川 750001,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,安徽济人药业有限公司, 安徽 亳州 236800,天津药物研究院, 中药现代制剂与质量控制技术国家地方联合工程实验室, 天津 300193;天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193,天津药物研究院, 天津市中药质量标志物重点实验室, 天津 300193;天津药物研究院 新药评价中心, 释药技术与药代动力学国家重点实验室, 天津 300193 |
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| 基金项目： | 国家中药标准化专项资助（ZYBZH-C-AH-02）；国家自然科学基金资助项目（81430096）；国家自然科学基金资助项目（81703802） |
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| 摘 要： | 目的探究疏风解毒胶囊治疗上呼吸道感染的配伍合理性。方法实验采用网络药理学的方法,对疏风解毒胶囊中清热解毒组、解表组和甘草组的32个化合物的作用靶点和通路进行预测和筛选,通过数据整合分析,剖析该方的作用特点及配伍规律。结果 32个化合物可作用于94个相关靶点和34条相关通路,主要涉及炎症反应、细菌脂多糖反应、免疫反应等相关过程。3组既有共同的作用靶点群及通路群,又各有偏重,协同发挥治疗作用。结论清热解毒组通过干预炎症反应、细菌脂多糖反应、防御反应和免疫反应等相关过程发挥治疗作用;解表组除可与清热解毒组协同发挥药效外,亦可通过多途径作用于发汗解热过程;甘草组从抗炎、增强机体免疫等方面起到辅助治疗作用,体现了疏风解毒胶囊的配伍合理性。
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| 关 键 词： | 网络药理学 疏风解毒胶囊 配伍合理性 上呼吸道感染 清热解毒 |
| 收稿时间： | 2018-08-23 |
Study on compatibility rationality of Shufeng Jiedu Capsule based on network pharmacology |
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| HAN Yan-qi,ZHU Qiang,DONG Ya-nan,XU Jun,GONG Su-xiao,ZHANG Hong-bing,PAN Jun,ZHANG Tie-jun and LIU Chang-xiao. Study on compatibility rationality of Shufeng Jiedu Capsule based on network pharmacology[J]. Chinese Traditional and Herbal Drugs, 2019, 50(15): 3547-3554 |
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| Authors: | HAN Yan-qi ZHU Qiang DONG Ya-nan XU Jun GONG Su-xiao ZHANG Hong-bing PAN Jun ZHANG Tie-jun LIU Chang-xiao |
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| Affiliation: | National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Anhui Jiren Pharmaceutical Co., Ltd., Bozhou 236800, China,Yinchuan Hospital of Traditional Chinese Medicine, Yinchuan 750001, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,Anhui Jiren Pharmaceutical Co., Ltd., Bozhou 236800, China,National & Local United Engineering Laboratory of Modern Preparation and Quality Control Technology of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and Tianjin Key Laboratory of Quality Marker of Traditional Chinese Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China;State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Center for New Drug Evaluation and Research, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Abstract: | |
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| Keywords: | network pharmacology Shufeng Jiedu Capsule compatibility rationality upper respiratory infection heat-clearing and detoxifying |
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