槐杞黄颗粒联合头孢他啶对肺炎支原体肺炎患儿炎性因子及免疫功能的影响

目的 研究槐杞黄颗粒联合注射用头孢他啶对肺炎支原体肺炎患儿炎性因子及免疫功能的影响。方法 选择2015年6月—2017年6月资阳市人民医院儿科门诊的81例肺炎支原体肺炎患儿为研究对象，将患儿随机分为对照组（41例）和观察组（40例）。对照组静脉滴注注射用头孢他啶，10 mg/kg加入到5%葡萄糖注射液100 mL，2次/d；观察组在对照组治疗的基础上口服槐杞黄颗粒，10 g/次，2次/d。两组均治疗3个月。观察两组患儿的临床疗效，比较两组患儿住院时间、临床症状消退时间、炎症因子和免疫功能。结果 观察组治疗的总有效率高于对照组（95.00% vs 73.17%， P<0.05）。治疗后，观察组患儿的肺部湿啰音消退时间、发热消退时间、住院时间和咳嗽喘息消失时间均明显短于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组的血清C反应蛋白（CRP）、白细胞介素（IL）-4以及IL-6水平均明显降低，IL-10水平均明显升高，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，观察组炎症因子水平明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组的CD4⁺/CD8⁺和CD4⁺均明显升高，CD8⁺明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；治疗后，观察组免疫功能指标明显优于对照组，两组比较差异有统计学意义（P<0.05）。结论 槐杞黄颗粒联合注射用头孢他啶对肺炎支原体肺炎患儿的治疗效果优于单纯使用头孢他啶钠，可以降低炎性因子水平，提升机体免疫功能。

Effect of Huaiqihuang Granules combined with ceftazidime on inflammatory factors and immune function in children with mycoplasma pneumoniae pneumonia

Objective To investigate the clinical effect of Huaiqihuang Granules combined with Ceftazidime for Injection on inflammatory factors and immune function in children with mycoplasma pneumoniae pneumonia. Methods Patients (81 cases) with mycoplasma pneumoniae pneumonia in Ziyang City People''s Hospital from June 2015 to June 2017 were randomly divided into control (41 cases) and observation (40 cases) groups. The control group were iv administered with Ceftazidime for Injection, 10 mg/kg added into 5% glucose injection 100 mL, twice daily. The observation group were po administered with Huaiqihuang Granules on the basis of control group, 10 g/time, twice daily. Children in two groups were treated for 3 months. After treatment, the clinical efficacies were observed, and the hospitalization time, clinical symptom subsided time, inflammatory factors, and immune functions in two groups were compared. Results After treatment, the effective rate of the observation group was 95.00%, which was significantly higher than 73.17% of the control group, and there was difference between two groups (P<0.05). After treatment, the pulmonary rales subsided time, fever subsided time, hospitalization time and cough and wheezing disappeared time in the observation groups were significantly shorter than those in the control group, and there was difference between two groups (P<0.05). After treatment, the serum CRP, IL-4 and IL-6 in two groups were significantly decreased, but the IL-10 level were increased, and the difference was statistically significant in the same group (P<0.05). After treatment, the inflammatory factors level in the observation group was significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, CD4⁺/CD8⁺ and CD4⁺ in two groups were significantly increased, CD8⁺ were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, the immune function indexes in the observation group was significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion The efficacy of Huaiqihuang Granules combined with Ceftazidime for Injection on children with mycoplasma pneumoniae pneumonia is better than that of ceftazidime alone, which can reduce the level of inflammatory factors, and enhance the immune function of children.