黄连生物碱类资源性化学成分研究进展与利用策略

作为大宗中药材的黄连由于应用范围广、所含生物碱类化合物是创新药物研究的主要前体化合物,一直是业界关注的重点。着重从中药产业发展的角度出发,系统综述黄连中主要药效成分——生物碱类资源性化学成分,基于生物碱成分的品质评价、结构修饰和产业化应用分析了黄连资源化学进展,并从资源性成分高值化利用和非传统药用部位开发利用等角度提出了黄连药材作为有限再生资源进行资源化利用的策略,以期能够发掘新药源、研究新用途,为黄连药材的开发与资源化循环利用提供参考。

Research progress and utilization strategy on alkaloid resource chemistry of Coptidis Rhizoma

Coptidis Rhizoma is one of the staple traditional Chinese medicinal materails in China with long officinal history, and its alkaloids provide the most important sources of precursor compounds in innovative drug research, which has been the focus of industry attention. This paper emphasized the industry development and summarized the alkaloid resource chemical constituents in Coptidis Rhizoma, and the progress of resource chemical research on Coptidis Rhizoma based on quality evaluation, structure modification and industrial application of the alkaloids was analyzed. The attention to the high value development of resource compounds and the use of "non-traditional medicinal tissues" for the limited resource Coptidis Rhizoma were proposed. The utilization ways and strategies provide important reference for the comprehensive development and resource recycling of Coptidis Rhizoma.