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电化学振荡指纹图谱在中药质量控制中的应用进展
引用本文:贾广成,王海霞,叶瑞平,裴洁荣,李正.电化学振荡指纹图谱在中药质量控制中的应用进展[J].中草药,2019,50(20):5064-5070.
作者姓名:贾广成  王海霞  叶瑞平  裴洁荣  李正
作者单位:天士力医药集团股份有限公司, 天津 300410,天津中医药大学中药制药工程学院, 天津 301617,天津中医药大学中药制药工程学院, 天津 301617,天津中医药大学中药制药工程学院, 天津 301617,天津中医药大学中药制药工程学院, 天津 301617
基金项目:国家“重大新药创制”科技重大专项(2018ZX09201011);天津市教委科研计划项目(2017KJ133);天津中医药大学第九届大学生科技创新基金项目(CXJJ2019YA04)
摘    要:由于中药成分复杂且来源不稳定,为药材及中药产品质量控制带来不便。指纹图谱技术是一种过程分析工具,为中药质控分析提供有效手段。其中,基于振荡化学的中药电化学指纹图谱检测方便、灵敏度高、准确度好,已应用于中药的定性、定量及制备过程工艺质量控制中。对振荡化学发展历程、振荡体系种类及振荡化学指纹图谱在中药材及其产品的全面质量控制方面的应用进行介绍,并指出目前其在数据测试及分析方面存在的问题及可能的改进方向,以期为中药科学化、系统化的质量控制提供新方法、新思路。

关 键 词:振荡化学  电化学指纹图谱  中药  质量控制  制药过程
收稿时间:2019/7/10 0:00:00

Application progress on electrochemical oscillation fingerprint in quality control of Chinese materia medica
JIA Guang-cheng,WANG Hai-xi,YE Rui-ping,PEI Jie-rong and LI Zheng.Application progress on electrochemical oscillation fingerprint in quality control of Chinese materia medica[J].Chinese Traditional and Herbal Drugs,2019,50(20):5064-5070.
Authors:JIA Guang-cheng  WANG Hai-xi  YE Rui-ping  PEI Jie-rong and LI Zheng
Institution:Tasly Pharmaceutical Group Co., Ltd., Tianjin 300410, China,College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China,College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China,College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China and College of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
Abstract:As is known to all, it is difficult for the quality control of herbs and products of Chinese materia medica (CMM) because of its complex composition and unstable source. Fingerprint technology is an effective process analysis tool, which can be used in the quality control of CMM. Among them, the electrochemical fingerprint method based on oscillatory chemistry is convenient, sensitive, and accurate, which has been used in qualitative and quantitative analysis and process quality control of CMM. In this paper, we reviewed the development history of oscillatory chemistry, the types of oscillatory systems, and the application of oscillatory chemical fingerprint in the quality control of herbs and products of CMM. Besides, the existing problems in data testing and analysis and the possible improvement direction have been introduced. The paper aimed to provide a new method or new idea for the scientific and systematical quality control of CMM.
Keywords:oscillating chemistry  electrochemical fingerprint  Chinese materia medica  quality control  pharmaceutical process
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