氧化苦参碱治疗慢性乙型肝炎的临床评价研究进展

氧化苦参碱多种途径给药（静脉滴注、肌肉注射或口服）治疗慢性乙型肝炎都有较好的疗效。氧化苦参碱的临床疗效与剂量和用药时间存在一定的相关性，其中与用药时间的关系更为密切。注射给药的疗效快于口服，因此治疗开始时可注射给药，随后改为口服给药以持续提高疗效。氧化苦参碱除直接的抗病毒、抗炎、肝脏保护作用外，还可通过提高患者的免疫调节作用，间接增强机体清除和抑制病毒的能力，这可能是其治疗乙型肝炎疗效持续稳定的作用机制。

Research advances on clinical evaluation on oxymatrine for treatment of chronic hepatitis B

Oxymatrine has clinical efficacy for the treatment of chronic hepatitis B by multiple routes of administration (intravenous drip, intramuscular injection or oral administration). The clinical efficacy of oxymatrine has a certain correlativity with dosage and administering time, the correlation with administering time is more intimate than to dosage. Clinical efficacy of injection is faster occurrence than oral, for this reason, oxymatrine treatment keep on a steady increase in the clinical efficacy. Except direct effects of anti-virus, anti-inflammation, and hepatoprotection, oxymatrine indirectly promotes ability of body to inhibit and eliminate virus by increasing immunoregulation of patient. This may be the effective mechanism of continued steady efficacy of oxymatrine for the treatment of hepatitis B.