| 基于药效物质基础的熟地黄质-效评价研究进展 |
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| 引用本文： | 杜珂,高晓霞,王锋,王佩义,秦雪梅. 基于药效物质基础的熟地黄质-效评价研究进展[J]. 中草药, 2019, 50(6): 1477-1484 |
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| 作者姓名： | 杜珂 高晓霞 王锋 王佩义 秦雪梅 |
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| 作者单位： | 山西大学 中医药现代研究中心, 山西 太原 030006;山西大学化学化工学院, 山西 太原 030006,山西大学 中医药现代研究中心, 山西 太原 030006,山西广誉远国药有限公司, 山西 太谷 030800,山西广誉远国药有限公司, 山西 太谷 030800,山西大学 中医药现代研究中心, 山西 太原 030006 |
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| 基金项目： | 山西省科技重点研发计划项目（201603D3113006）;山西省重点实验室项目（201605D111004）;山西省科技创新重点团队项目（201605D131045-18） |
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| 摘 要： | 通过综述熟地黄的化学成分、活性成分药理作用、炮制研究,阐释熟地黄的药效物质基础,从整体的角度探究不同炮制程度熟地黄的全面质-效评价,以期揭示熟地黄炮制的科学内涵,为熟地黄的质-效评价和炮制终点的确定提供新的思路。
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| 关 键 词： | 熟地黄 药效物质基础 炮制 代谢组学 质-效评价 |
| 收稿时间： | 2018-11-12 |
Research progress on quality and efficacy evaluation of Rehmanniae Radix Praeparata based on pharmacodynamic material basis |
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| DU Ke,GAO Xiao-xi,WANG Feng,WANG Pei-yi and QIN Xue-mei. Research progress on quality and efficacy evaluation of Rehmanniae Radix Praeparata based on pharmacodynamic material basis[J]. Chinese Traditional and Herbal Drugs, 2019, 50(6): 1477-1484 |
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| Authors: | DU Ke GAO Xiao-xi WANG Feng WANG Pei-yi QIN Xue-mei |
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| Affiliation: | Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China;College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China,Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China,Shanxi Guangyuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China,Shanxi Guangyuyuan Traditional Chinese Medicine Co., Ltd., Taigu 030800, China and Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China |
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| Abstract: | The chemical constituents, pharmacological action of active components, and processing of Rehmanniae Radix Praeparata were reviewed in this study to explain its pharmacodynamic material basis and explore the quality and efficacy evaluation of Rehmanniae Radix Praeparata with different processing degrees from the view of the whole. This paper is expected to reveal the scientific connotation of processing, providing new research ideas for the quality and efficacy evaluation and the determination of the possessing end-point of Rehmanniae Radix Praeparata. |
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| Keywords: | Rehmanniae Radix Praeparata pharmacodynamic material basis processing metabonomics quality and efficacy evaluation |
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