丹参川芎嗪联合阿托伐他汀对2型糖尿病合并颈动脉粥样硬化患者的血脂及颈动脉血流参数的影响

目的 探究丹参川芎嗪注射液联合阿托伐他汀钙片对2型糖尿病合并颈动脉粥样硬化患者血脂及颈动脉血流参数的影响。方法 选取2016年3月-2018年5月杨凌示范区医院收治的80例2型糖尿病合并颈动脉粥样硬化患者，根据入院顺序随机分为对照组和观察组，每组各40例。对照组在常规控制血糖的基础上口服阿托伐他汀钙片，10 mg/次，2次/d；观察组在对照组的基础上静脉滴注丹参川芎嗪注射液，10 mL用生理盐水稀释至250 mL，1次/d。两组均治疗6个月。比较治疗前后两组患者血脂及颈动脉血流参数。结果 治疗后，两组三酰甘油（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDLC）均明显低于治疗前，高密度脂蛋白胆固醇（HDL-C）明显高于治疗前，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组各指标明显优于对照组，两组比较差异有统计学意义（P<0.05）。治疗后，两组阻力指数（RI）、搏动指数（PI）均明显低于治疗前，血液平均流速（V_mean）与收缩期血液峰值流速（PSV）均明显高于治疗前，同组治疗前后比较差异具有统计学意义（P<0.05）；且观察组各指标显著优于对照组，两组比较差异具有统计学意义（P<0.05）。结论 丹参川芎嗪注射液联合阿托伐他汀钙片治疗2型糖尿病合并颈动脉粥样硬化可有效降低患者血脂水平，改善颈动脉血流参数，从而改善颈动脉粥样硬化，值得临床推广应用。

Effects of salviae miltiorrhizae and ligustrazine hydrochloride combined with atorvastatin on blood lipids and carotid blood flow parameters in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis

Objective To investigate the effects of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets on blood lipid and carotid blood flow parameters in patients with type 2 diabetes mellitus complicated with carotid atherosclerosis. Methods Patients (80 cases) with type 2 diabetes mellitus complicated with carotid atherosclerosis in Yangling Demonstration Zone Hospital from March 2016 to May 2018 were divided into control and observation groups according to the order of admission, and each group had 40 cases. The control group was treated with Atorvastatin Calcium Tablets based on routine of blood glucose control. The observation group were iv administered with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of the control group, 10 mL diluted to 250 mL with normal saline, once daily. Patients in two groups were treated for 6 months. After treatment, the levels of blood lipid and carotid blood flow parameters before and after treatment in two groups were compared. Results After treatment, the levels of TG, TC and LDL-C in two groups were significantly lower than those before treatment, but HDL-C was significantly higher than before, and the difference was statistically significant in the same group (P<0.05), and the indexes in the observation group was significantly better than those in the control group, with significant difference between two groups (P<0.05). After treatment, RI and PI in two groups were significantly lower than those before treatment, but V_mean and PSV were significantly higher than before, and the difference was statistically significant in the same group (P<0.05). And the parameters in the observation group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with Atorvastatin Calcium Tablets in treatment of type 2 diabetes mellitus complicated with carotid atherosclerosis can significantly reduce blood lipid levels, and improve carotid blood flow parameters, thereby improving carotid atherosclerosis, which has a certain clinical application value.