围绝经期妇女血清铁蛋白水平和股骨颈骨强度相关性研究

目的探索围绝经期妇女血清铁蛋白与股骨颈强度综合指数之间的关系。方法选择2014年7月至2017年12月在我院就诊的116例围绝经期妇女纳入本研究。使用双能X射线吸收扫描仪测量髋部骨几何结构性质,包括髋轴长度(HAL)和股骨颈宽度(FNW),并将其与BMD,体重和身高结合以产生股骨颈的综合指数(CSI)、弯曲(BSI)和冲击强度指数(ISI)三种不同的失效模式下的强度。结果在对年龄、体质量指数(BMI)、生活方式因素、血清25-羟基维生素D、钙和磷摄入量、糖尿病和更年期状态进行校正后,多元回归分析显示血清铁蛋白与腰椎和股骨颈,以及股骨颈皮质厚度密切相关。重要的是,在所有的调整模型中,血清铁蛋白与三种股骨颈综合指数(如CSI、BSI和ISI)显示负相关(P0.05)。结论本研究表明高血清铁蛋白反映的全身铁储存增加可能与骨强度相对于负荷的减少有关。

Study on the correlation between serum ferritin and femur bone strength in postmenopausal women

Objective To explore the relationship between serum ferritin and femoral neck strength index in postmenopausal women. Methods We selected 116 perimenopausal women who were present in our hospital from July 2014 to December 2017 to participate in this study. Geometric bone structure properties, including hip axis length (HAL) and femur neck width (FNW), were measured using dual-energy X-ray absorptiometry scans and were combined with bone mineral density (BMD), body weight, and height to create composite indices of femur neck strength relative to load in three different failure models, compression (CSI), bending (BSI), and impact strength indices (ISI). Results After adjustment for age, body mass index (BMI), lifestyle factors, serum 25-hydroxyvitamin D, calcium and phosphorus intake, diabetes, and menopause status, multiple regression analyses revealed that serum ferritin was inversely associated with BMD values at the lumbar spine and femur neck and the cortical thickness of the femur neck. Importantly, in all adjustment models, higher serum ferritin was consistently associated with the lower values for all three femur neck composite indices, such as CSI, BSI, and ISI (P<0.05). Conclusion The results of the study suggest that the increase in systemic iron stores reflected by high serum ferritin may be related to a decrease in bone strength relative to the load.