泮托拉唑对比奥美拉唑治疗胃溃疡的Meta-分析

目的 系统评价泮托拉唑对比奥美拉唑治疗胃溃疡的疗效和安全性。方法 计算机检索PubMed、EmBase、Cochrane Library、中国学术期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、维普中文期刊全文数据库（VIP）和万方数据库，从建库至2018年7月公开发表的泮托拉唑和奥美拉唑治疗胃溃疡的随机临床对照试验（RCT），由两位研究者独立筛选评价文献并提取资料，采用RevMan 5.3软件行系统评价。结果 共纳入15项RCTs，合计1 482例患者。Meta-分析结果显示：泮托拉唑组相对于奥美拉唑组在溃疡治愈率［RR=1.12，95% CI（1.02，1.24），P=0.02］和幽门螺杆菌根除率［RR=1.40，95% CI（1.22，1.61），P<0.000 01］方面的差异均有统计学意义；两组总有效率［RR=1.03，95% CI（1.00，1.07），P=0.09］以及不良反应发生率［RR=1.34，95% CI（0.89，2.04），P=0.16］比较无显著性差异。结论 泮托拉唑的胃溃疡治愈率和幽门螺杆菌根除率优于奥美拉唑，两者总有效率和不良反应发生率相当，安全性、耐受性均较好。

Meta-analysis of pantoprazole versus omeprazole in treatment of gastric ulcer

Objective To systematically review the efficacy and safety of pantoprazole versus omeprazole in treatment of gastric ulcer (GU). Method Retrieving published randomized controlled clinical trials about pantoprazole versus omeprazole in treatment of gastric ulcer in PubMed, EmBase, Cochrane Library, CNKI, CBM, VIP and Wanfang from the foundation of database to July 2018, then making the Meta-analysis by RevMan 5.3. Results A total of 15 RCTs involving 1 482 patients were included. The Metaanalysis results showed that compared with omeprazole, there was a significant difference (P<0.05) in treatment group with regard to GU cure rate[RR=1.12, 95%CI(1.02, 1.24), P=0.02] and Helicobacter pylori eradication rate[RR=1.40, 95%CI(1.22, 1.61), P< 0.000 01]. There were no significant differences (P>0.05) among the total effective rate[RR=1.03, 95%CI(1.00, 1.07), P=0.09] and adverse reaction (ADR) incidence[RR=1.34, 95%CI(0.89, 2.04), P=0.16] in 2 groups. Conclusion The cure rate and H.pylori eradication rate of pantoprazole are better than omeprazole. Pantoprazole and omeprazole have similar total effective rate and ADR incidence in the treatment of GU. The safety and tolerance are all acceptable.