温度敏感性生物材料研究进展

目的：总结近年来温度敏感性生物材料（简称温敏材料）的研究进展，为后续温敏材料的进一步研究提供参考。方法：通过文献研究，总结目前常用的几种温敏材料的组成、原理，并介绍其在药物释放方面的应用。结果：温敏材料具有良好的生物相容性与低细胞毒性，常见的有壳聚糖聚合物、聚N-异丙基丙烯酰胺聚合物等，其温敏性决定了在药物释放中的作用，提高了药物靶向性。结论：温敏材料可受环境因素影响发生体积相变，是药物缓控释的优秀材料。设计性能优良的温敏材料并成功应用于临床将是未来的研究方向之一。

On Research Progress of Thermo-sensitive Biomaterials

Objective: To summarize the research progress of thermo-sensitive biomaterials in recent years in order to provide references for further research of subsequent thermo-sensitive biomaterials. Methods: The composition and principles of several commonly used thermo-sensitive materials were summarized through literature review, and their application in drug delivery was also introduced in this paper. Results: Thermosensitive biomaterials have good biocompatibility and low cytotoxicity. Chitosan or poly (N-isopropylacrylamide) (PNIPAM), as representative materials, can be used to control drug release because of thermosensitivity. Besides, they can improve the targeting. Conclusion: The volume of thermo-sensitive materials may change under the influence of environmental factors, and this property makes it a prosperous candidate for drug controlled release. Designing thermo-sensitive materials with excellent properties and applying them in clinic successfully will be one of the future research directions.