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| Localization and Biodistribution of Conjugate ATG－Dex－DNR in Nude Mice as Models for Human Leukemia | |
| 引用本文： | 张东华,唐锦治,李志雄,崔武任,吴华,朱慧芬,沈关心. Localization and Biodistribution of Conjugate ATG－Dex－DNR in Nude Mice as Models for Human Leukemia[J]. 华中科技大学学报(医学英德文版), 1995, 15(2): 82-86. DOI: 10.1007/BF02887907 |
| 作者姓名： | 张东华 唐锦治 李志雄 崔武任 吴华 朱慧芬 沈关心 |
| 作者单位： | ZHANG Dong-hua; TANG Jin-zhi; LI Zhi-xiong;CUI Wu-ren; WU Hua; ZHU Hui-fen;SHEN Guan-xin (Department of Internal Medicine，Tongji Hospital，Tongji Medical University，Wuhan 430030 |
| 摘 要： | ＬｏｃａｌｉｚａｔｉｏｎａｎｄＢｉｏｄｉｓｔｒｉｂｕｔｉｏｎｏｆＣｏｎｊｕｇａｔｅＡＴＧ－Ｄｅｘ－ＤＮＲｉｎＮｕｄｅＭｉｃｅａｓＭｏｄｅｌｓｆｏｒＨｕｍａｎＬｅｕｋｅｍｉａＺＨＡＮＧＤｏｎｇ－ｈｕａ（张东华），ＴＡＮＧＪｉｎ－ｚｈｉ（唐锦治），ＬＩＺ... |
| 收稿时间： | 1994-10-26 |
Localization and biodistribution of conjugate ATG-Dex-DNR in nude mice as models for human leukemia |
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| Zhang Dong-hua,Tang Jin-zhi,Li Zhi-xiong,Cui Wu-ien,Wu Hua,Zhu Hui-fen,Shen Guan-xin. Localization and biodistribution of conjugate ATG-Dex-DNR in nude mice as models for human leukemia[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1995, 15(2): 82-86. DOI: 10.1007/BF02887907 | |
| Authors: | Zhang Dong-hua Tang Jin-zhi Li Zhi-xiong Cui Wu-ien Wu Hua Zhu Hui-fen Shen Guan-xin |
| Affiliation: | (1) Department of Internal Medicine, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Research Center of Experimental Medicine, Tongji Medical University, 430030 Wuhan;(3) Department of Nuclear Medicine, Tongji Hospital, Tongji Medical University, 430030 Wuhan |
| Abstract: | I-labelled anti-thymoglobuline (ATG), 131 I-labelled immunoconjugate ATG-Dex-DNR and 131 I-labelled Ts-MoAb as control antibody, respectively.were injected by intraperitoneal (i. p.) administration into nude mice used as models for human T-cell leukemia. SPECT imaging was performed from day 1 to day 8 following i. p. injection. The results showed that radioimmunoimaging of buman tumor xenografts was clearest day 3 after injection in both of ATG and ATG-Dex-DNR groups, whereas it's not the case in Ts-MoAb group. Nude mice were killed 8th day after injection with antibody or conjugate. The tumor, as well as different dissected normal organs including heart, liver, lungs, kidney, femur and intestine, were harvested, weighed precisely, and radioiodine-counted. T/NT ratios in experimental group was greater than 1. 0 (ranged from 1. 246-7. 865). and in control group they were less than 1. 0 (ranged from 0. 263-0. 757, except for tumor/femur ratio). Our results indicated that ATG and ATG-Dex-DNR had specific affinity to cell line of Tcell leukemia CEM. |
| Keywords: | ATG immunoconjugate radioimmunoimaging human leukemia modelbearing nude mice |
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