| 高效液相色谱法测定消炎止咳片中盐酸麻黄碱含量 |
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| 引用本文： | 郭德勇,陶礼萍,宋国清,毛慧芳. 高效液相色谱法测定消炎止咳片中盐酸麻黄碱含量[J]. 中国药业, 2007, 16(24): 31-32 |
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| 作者姓名： | 郭德勇 陶礼萍 宋国清 毛慧芳 |
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| 作者单位： | 浙江一新制药股份有限公司,浙江,兰溪,321100 |
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| 摘 要： | 目的 用高效液相色谱（HPLC）法测定消炎止咳片的盐酸麻黄碱含量。方法 色谱柱为Alltech C18柱（150mm×4．6mm，5μm），流动相为乙腈-0．1％磷酸溶液（5：95），检测波长207nm，流速为1．0mL／min。结果 盐酸麻黄碱质量浓度线性范围为4．34～26．04μg／mL（r=0．9999），平均回收率为99．58％，RSD为1．36％。结论 HPLC法精密度好，结果准确，可作为消炎止咳片的盐酸麻黄碱含量测定方法。
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| 关 键 词： | 高效液相色谱法 消炎止咳片 盐酸麻黄碱 |
| 文章编号： | 1006-4931(2007)24-0031-02 |
| 修稿时间： | 2007-04-06 |
Determination of Ephedrine Hydrochloride in Xiaoyanzhike Tablet by HPLC |
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| Guo Deyong,Tao Liping,Song Guoqing,Mao Huifang. Determination of Ephedrine Hydrochloride in Xiaoyanzhike Tablet by HPLC[J]. China Pharmaceuticals, 2007, 16(24): 31-32 |
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| Authors: | Guo Deyong Tao Liping Song Guoqing Mao Huifang |
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| Affiliation: | Guo Deyong , Tao Liping , Song Guoqing , Mao Huifang ( Zhejiang yixin Pharmaceutical Co., Ltd, Lanxi, Zhejiang, China 321100) |
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| Abstract: | Objective To establish a HPLC method for the determination of ephedrine hydrochloride in Xiaoyanzhike Tablet. Methods Alltech C18 column（ 150 mm × 4.6 mm, 5μm） was used, acetonitrile - 0.1% phosphoric acid（5 ： 95 ） as the mobile phase. The detection wavelength was 207 nm,the flow rate was 1.0 mL/min. Results The calibration curve was linear in the range of 4.34- 26.04μg/mL（ r =0. 999 9）. The average recovery rate was 99.58%, RSD was 1.36%. Conclusion The method is accurate,reliable. It can be used for the quality control of Xiaoyanzhike Tablet. |
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| Keywords: | HPLC Xiaoyanzhike Tablet ephedrine hydrochloride |
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