新疆地区维吾尔族与汉族慢性胃炎患者间幽门螺杆菌不同抗体的情况分析

目的探讨新疆地区维吾尔族与汉族慢性胃炎患者与幽门螺杆菌不同抗体的关系。 方法纳入2014年1至8月新疆维吾尔自治区人民医院诊断为慢性胃炎的患者198例，维吾尔族96例，汉族102例，均行幽门螺杆菌、幽门螺杆菌分型检测及胃十二指肠镜检查并活检，用χ²检验分析两组间幽门螺杆菌不同抗体的阳性率是否存在差异，对有差异者进行相关性分析。 结果本研究中幽门螺旋杆菌5种不同抗体阳性率，维吾尔族较汉族明显增高；维吾尔族与汉族间CagA-128KD、VacA-110KD、VacA-90KD、UreB-66KD及UreA-30KD的阳性率比较，差异有统计学意义(P<0.001)；CagA-128KD、VacA-110KD、VacA-90KD、UreB-66KD及UreA-30KD与维吾尔族慢性胃炎患者相关，其中与CagA-128KD密切相关(r＝0.506、0.410、0.273、0.285、0.277，P<0.001、<0.001、<0.05、<0.05、<0.05)。 结论维吾尔族慢性胃炎患者较汉族慢性胃炎患者幽门螺旋杆菌5种不同抗体阳性率明显高，维吾尔族慢性胃炎患者与CagA-128KD密切相关。

Positive rate Investigation of the relationship between the types of different helicobacter pylori strains and Chronic gastritis in Xinjiang

ObjectiveTo explore the relationship between the types of Helicobacter pylori strains and Chronic gastritis among Uyghur and Han Chinese in Xinjiang. MethodsFrom January 2014 to August 2014, there were 198 cases of patients with chronic gastritis: 96 cases of Uighur and 102 cases of Han.All of them were adopted Helicobacter pylori, detecting and typing Helicobacter pylori, gastroduodenoscopy and biopsy, analyzed the difference of with χ² test helicobacter pylori antibody positive rate of different between the two groups whether there is any difference, the difference is analyzed. ResultsThe positive rate of H. pylori strains(CagA-128KD、VacA-110KD、VacA-90KD、UreB-66KD and UreA-30KD)were differed significantly between Uygur and Han Chinese P<0.001), Uygur are high compared with Han nationality; Serum CagA-128KD、VacA-110KD、VacA-90KD、UreB-66KD and UreA-30KD genes are associated with Gastritis in Uyghur (r=0.506、0.410、0.273、0.285、0.277, P<0.001、<0.001、<0.05、<0.05、<0.05). ConclusionUyghur than han Chinese patients with chronic gastritis patients with chronic gastritis helicobacter pylori five different antibodies positive ratio is high, the uygur patients with chronic gastritis is closely related to the CagA-128 kd.