宫外生长发育迟缓早产儿住院期间年龄别体质量Z评分的变化

目的了解宫外生长发育迟缓早产儿住院期间年龄别体质量Z评分(WAZ)的变化。 方法采用回顾性调查方法，收集2010年12月1日至2013年11月30日，淮安市妇幼保健院新生儿重症监护中心收治的300例早产儿临床资料。根据宫外生长发育迟缓(EUGR)诊断标准，分为EUGR组和非EUGR组，计算及观察不同组别小胎龄早产儿住院期间的WAZ值变化。 结果EUGR早产儿122例，发生率为40.7%。两组早产儿的WAZ值均为负值，EUGR组的WAZ值随周龄增加而降低。EUGR组在出生时(－0.83±0.37；－0.25±0.39)、生后第1周(－1.16±0.35；－0.54±0.43)、生后第2周(－1.14±0.35；－0.46±0.46)、生后第3周(－1.21±0.34；－0.58±0.39)、生后第4周(－1.35±0.41；－0.65±0.42)、出院时(－1.68±0.38；－0.52±0.44)WAZ值均低于非EUGR组，差异有统计学意义(Z＝10.72，11.00，11.47，10.72，8.91，14.42；均P＝0.000)。 结论EUGR早产儿住院期间的WAZ值较同参照人群均值水平的差距随周龄的增加而增大，关注WAZ值的动态变化，对早发现EUGR有一定的临床意义。

The variation of weight for age Z score in preterm infants with extrauterine growth restriction

ObjectiveTo explore the variation of weight for age Z score in preterm infants with extrauterine growth restriction (EUGR)during the hospitalization. MethodsData of the premature infant from the Neonatal intensive care unit of Huai′an Maternity and Child Healthcare Hospital from December 1, 2010 to November 30, 2013 were collected retrospectively.The criteria for enrollment were gestational age <32 weeks, within the first 24 hours of life and survived when discharged, and hospitalization period ≥2 weeks.With the criteria, all of the premature infants were divided into extrauterine growth restriction (EUGR) group and non-EUGR group.And then, WAZ score count of each specific group was described to observe their growth situation during the hospitalization. ResultsPreterm infants with EUGR were 122 cases, the incidence of EUGR assessed by weight was 40.7%.WAZ scores of the EUGR group and non-EUGR group were almost negative. Z score of the EUGR group was lower than that of the control group.All of the WAZ scores were showed significant difference (Z=10.72, 11.00, 11.47, 10.72, 8.91, 14.42 respectively, P<0.05) between the EUGR and non-EUGR group in each observing time, such as at birth (-0.83±0.37, -0.25±0.39), the 1st week (-1.16±0.35, -0.54±0.43), the 2nd week (-1.14±0.35, -0.46±0.46), the 3rd week (-1.21±0.34, -0.58±0.39), the 4th week (-1.35±0.41, -0.65±0.42), and at the discharged time(-1.68±0.38, -0.52±0.44). ConclusionsThe weight for age Z score in preterm infants with EUGR show a progressive decline.The WAZ score′ variation tendency have some clinical significance to prevent EUGR.