益生菌用于重度急性胰腺炎治疗的Meta分析

 目的 用Meta分析的方法评价益生菌用于治疗重度急性胰腺炎(severe acute pancreatitis, SAP)的效果。方法 检索PubMed、The Cochrane Library、中国生物医学文献数据库(CBM)、中文科技期刊数据库(维普),中国期刊全文数据库(CNKI),万方学术期刊全文数据库,全面查找益生菌治疗SAP的文献,评价纳入文献的方法学质量,用RevMan5.0软件统计分析。结果 共纳入7篇文献,共有SAP患者654例,Meta分析结果显示实验组与对照组在病死率(RR=1.29, 95% CI:0.77~2.16,P=0.33)、多器官衰竭发生率(RR=0.81, 95%CI:0.52~1.24,P=0.33)、感染性并发症发生率(RR=0.72, 95%CI:0.37~1.39,P=0.33)及抗生素使用率(RR=0.89, 95% CI:0.71~1.10,P=0.28)方面均无统计学差异,但在胰腺脓肿发生率(RR=0.53, 95% CI:0.28~0.98,P=0.04)方面存在统计学差异。结论 益生菌不能降低SAP患者感染性并发症发生率、多器官衰竭发生率、抗生素使用率和病死率,但可能降低胰腺脓肿发生率。

Meta-analysis of efficacy of probiotics for severe acute pancreatitis

Objective To use method of the meta-analysis for evaluating efficacy of probiotics applied to severe acute pancreatitis. Methods The PubMed, The Cochrane Library, CBM database, VIP database, CNKI database, and Wanfang database were searched, comprehensive literature search of the probiotics usage in the treatment of severe acute pancreatitis, and the methodological quality of literatures was evaluated. RevMan 5.0 software was used to conduct statistics and analysis. Results The study participants included 7 articles, a total of 654 patients with severe acute pancreatitis. There were no statistically significant differences in mortality (RR=1.29, 95%CI:0.77-2.16,P=0.33), multiple organ failure incidence (RR=0.81, 95%CI:0.52-1.24,P=0.33), infectious complications incidence(RR=0.72, 95%CI:0.37-1.39,P=0.33)and antibiotics usage(RR=0.89, 95% CI:0.71-1.10,P=0.28)between experimental group and control group. But there was significant statistical difference in pancreatic abscess incidence(RR=0.53, 95%CI:0.28-0.98,P=0.04). Conclusions According to the current research data, probiotics in SAP patients have no positive effects on mortality,multiple organ failure incidence, infectious complications incidence and antibiotics usage. But they can reduce the incidence of pancreatic abscess.