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| 胞外信号调控激酶（ERK）信号通路与抑郁症 | |
| 引用本文： | 李牧函,余冰颖,刘屏. 胞外信号调控激酶（ERK）信号通路与抑郁症[J]. 神经药理学报, 2015, 5(1): 38 |
| 作者姓名： | 李牧函 余冰颖 刘屏 |
| 作者单位： | 1．解放军总医院临床药理研究室，北京， 100853，中国2．北京中医药大学，北京，100029，中国3．河北北方学院，张家口，075000，中国 |
| 基金项目： | 国家自然科学基金资助（No.81173430） |
| 摘 要： | 胞外信号调控激酶（extracellular signal-regulated kinase，ERK）信号通路对神经细胞的生长、增殖、分化和存活起关键调节作用，并且对脑内突触可塑性和学习记忆有重要影响，因此ERK信号通路逐渐成为抗抑郁机制的研究热点。本文综述了近年来ERK信号通路在抑郁症发生和治疗方面的作用和机制，供同行参考。 |
| 关 键 词： | 胞外信号调控激酶（ERK） 信号通路 抑郁症 |
Extracellular Signal Regulated Kinase (ERK) Signaling Pathway and Depression |
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| LI Mu-han,YU Bing-ying,LIU Ping. Extracellular Signal Regulated Kinase (ERK) Signaling Pathway and Depression[J]. Journal of Hebei North University(Medical Edition), 2015, 5(1): 38 | |
| Authors: | LI Mu-han YU Bing-ying LIU Ping |
| Affiliation: | 1. Department of Clinical Pharmacology, Chinese PLA General Hospital, Beijing, 100853, China 2. Beijing University of Chinese Medicine, Beijing, 100029, China 3. Hebei North University, Zhangjiakou, 075000, China |
| Abstract: | The extracellular signal regulated kinase（ ERK） signal pathway plays a key role in the growth，proliferation，differentiation and survival of neurons and has important effects on synaptic plasticity and learning and memory in the brain. Therefore，ERK signaling pathway has become a hot research topic in the research of anti-depression mechanism. This paper reviews the role and mechanism of ERK signaling pathway in the pathogenesis and treatment of depression in recent years. |
| Keywords: | extracellular signal regulated kinase (ERK) signaling pathway depression |
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