应用CTA对无症状非糖尿病高危人群冠状动脉粥样硬化的研究

 目的 应用冠状动脉CT血管成像技术(computed tomography angiography,CTA)确定有高危因素,且非糖尿病无冠心病症状者冠状动脉粥样硬化(coronary atherosclerotic, CA)发生率,评价其与高危因素的相关性。方法 在非糖尿病无冠心病症状健康查体的人群中,收集有高危因素(性别、年龄、高血压、高脂血症)者并将其分为单项高危因素组、2项及以上高危因素组。统计有高危因素者冠状动脉粥样硬化发生率。结果 单因素分析发现,年龄和性别对CA的发生率有统计学差异(χ² ＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108)。高危因素logistic回归分析得出,年龄与CA的发生率有相关性(OR＝1.77,CI＝1.19～2.66)。高危因素组间比较,多项高危因素CA的发生率有统计学差异(χ²＝4.44,P=0.035)。结论 在非糖尿病无症状人群中,CTA能够在一次扫描提供冠状动脉斑块的重要信息,性别、年龄可能对发生CA病变带来更大的风险,作为一项无创性的检查,CTA在CA的诊断中发挥重要作用。

A study of computed tomography angiography (CTA) on coronary atherosclerosis in risk factors asymptomatic population

Objective To make use of coronary CTA to determine the incidence rate of coronary atherosclerosis for non-diabetic asymptomatic people who have risk factors and evaluate its correlation with risk factors. Methods We recruited non-diabetic asymptomatic people who had high-risk factors (sex, age, hypertension, hyperlipidaemia) and divided them into single high-risk factor group and multiple high-risk factors group. Statistics was conducted on the incidence rate of disease for people who had high-risk factors in coronary atherosclerosis. Results Single risk factor grouping analysis showed that gender and age had significant difference in the incidence of CA(χ²＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108) . For risk factors between groups, the incidence of multiple risk factors CA had significant difference (χ²＝4.6,P＝0.0032,χ²＝6.5,P＝0.0108). Logistic regression analysis showed that risk factors correlated with age and incidence of CA (OR＝1.77, CI＝1.19-2.66). Conclusions In asymptomatic non-diabetic population, CTA provides important information about coronary plaque in one scan, gender and age may have a greater risk of CA disease. As a non - invasive examination, CTA plays an important role in the diagnosis of CA.