环磷酰胺冲击联合激素与单纯激素治疗狼疮性肾炎的随机对照试验

目的：了解环磷酰胺间歇冲击加激素治疗狼疮性肾炎的短期和中期疗效。方法：将27例重症狼疮性肾炎患者随机分为两组。单纯治疗组用泼尼松治疗，联合治疗组用环磷酰胺间歇冲击加泼尼松治疗。疗程约1．5年，随访4年。结果：治疗结束时，两组的多个单项疗效指标和综合疗效指标的差异具有显著性（P＜0．05）；随访4年后，两组的复发率具有显著性差异（P＜0．05）。结论：联合治疗组的短期和中期疗效优于单纯治疗组。

Randomized ControlledStudy on the Effects of Intensive Cyclophosphamide Therapy Plus Corticosteroids andCorticosteroids-alone Treatment for Lupus Nephritis

To investigate the short and long-term effects of intensive cyclophosphamide therapy plus corticosteroids on lupus mephritis, 27 patients with severe lupus nephritis were divided into two groups. Patients in group 1 received prednisone alone and patients in group 2 were given intensive cyclophosphamide therapy plus corticosteroids. The treatment course lasted for 1.5 years and the patients were followed up for 4 years. At the end of the treatment, the differences in indicators, single or comprehensive, of effieacy were statistically signifieant(P＜0.05) between the two groups. A four-year follow-up showed that the difference in relapse was significant(P＜0.05). It is concluded that the intensive cyclophosphamide therapy plus corticosteroids on lupus nephritis was better than that of predinison-alone treatment in our series in terms of short-term and long-term effects on lupus nephritis.