| 地塞米松缓释微粒在增生性玻璃体视网膜病变的应用 |
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| 引用本文： | 张皙,张喜梅,蔡文泉,李佩娟.地塞米松缓释微粒在增生性玻璃体视网膜病变的应用[J].临床眼科杂志,2003,11(1):3-5. |
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| 作者姓名： | 张皙 张喜梅 蔡文泉 李佩娟 |
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| 作者单位： | 200080,上海市第一人民医院眼科 |
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| 摘 要： | 目的：观察含地塞米松（DEX）的缓释微粒治疗增生性玻璃体视网膜病变（PVR）的临床疗效。方法：9例（9只眼）视网膜脱离伴PVR患者进行常规玻璃体视网膜手术，并在玻璃体腔内植入1粒DEX微粒（含地塞米松1mg），观察术后反应及视力、PVR发展、DEX的位置及形状变化等。结果：术后炎症反应轻，7只眼视网膜复位，3只眼后极部视网膜前有增生；2只眼视网膜局限性脱离，最终3只眼玻璃腔内硅油填充。随访视力有8只眼较术前提高（P=0.015）。DEX未见对视网膜有不良影响，仅在随着处有少量色素吸附，4-6月后吸收。结论：DEX抑制PVR术后炎症反应及较远期作用是安全、有效的；对手术未完全清除的视网膜前增生有一定的抑制作用。
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| 关 键 词： | 地塞米松缓释微粒 增生性玻璃体视网膜病变 临床应用 疗效 术后 炎症 |
| 修稿时间： | 2002年10月21 |
Dexamethasone drug delivery system in treating proliferative vitreoretinopathy |
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| Zhang Xi,Zhang Ximei,Cai Wenquan,et al..Dexamethasone drug delivery system in treating proliferative vitreoretinopathy[J].Journal of Clinical Ophthalmology,2003,11(1):3-5. |
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| Authors: | Zhang Xi Zhang Ximei Cai Wenquan |
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| Institution: | Zhang Xi,Zhang Ximei,Cai Wenquan,et al.Department of Ophthalmology,Shanghai First People's Hospital,Shanghai 200080,China |
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| Abstract: | Objective To evaluate the clinical efficacy of an intraocular biodegradable polymer dexamethason drug (DEX) in treating proliferative vitreoretinopathy(PVR).Methods Nine patients(9 eyes) with RD and PVR underwent pars plana vitrectomy (PPV) with an intraocular DEX delivery drug system (DEX-DDS) implantation into vitreous cavity.The follow-up early inflammation,visual acuity(VA),PVR development,position and shape change of DEX were observed.Results The early inflammation was slight,retinal attachment in 7 eyes,PVR development in 3 eyes,limited retinal detachment in 2 eyes,silicone oil tampanade in 3 eyes.The follow-up best VA was markedly improved in 8 eyes than before operation (P=0.015).Conclusion DEX-DDS can prevent postoperative PVR and inflammation more safely and effectively. |
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| Keywords: | Dexamethasone drug delivery system(DEX) Proliferative vitreoretinopathy(PVR) |
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