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| 我国川贝母的质量分析 | |
| 引用本文： | 刘薇,张文娟,林丽君,魏锋,马双成. 我国川贝母的质量分析[J]. 中国药学杂志, 2015, 50(4): 305-309. DOI: 10.11669/cpj.2015.04.009 |
| 作者姓名： | 刘薇 张文娟 林丽君 魏锋 马双成 |
| 作者单位： | 1. 中国食品药品检定研究院,北京100050; 2. 深圳市罗湖区中医院, 广东 深圳 518001 |
| 基金项目： | 国家十二五“重大新药创制”专项(2014ZX09304307-002);国家自然科学基金青年项目(81202909) |
| 摘 要： | 目的 通过对2013年72批川贝母药材及饮片全国抽验情况,总结我国川贝母的质量问题,并探讨聚合酶链式反应-限制性内切酶长度多态性方法在检验中应注意的问题。方法 参照《中国药典》2010年版一部标准方法,对所抽取的样品进行检验和研究,发现并探讨其质量问题和检测方法。结果 抽验结果表明,市场上川贝母的不合格率为25.4%,聚合酶链式反应-限制性内切酶长度多态性方法在检验中对取样环节应予以明确规定。结论 应进一步完善和提高标准,加强质量监管,并建立专项抽验的长效机制,保证中药材及饮片的质量和安全。 |
| 关 键 词： | 川贝母 质量分析 标准方法 |
| 收稿时间： | 2015-03-09; |
Quality Analysis of Fritillariae Cirrhosae Bulbus |
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| LIU Wei,ZHANG Wen-juan,LIN Li-jun,WEI Feng,MA Shuang-cheng. Quality Analysis of Fritillariae Cirrhosae Bulbus[J]. Chinese Pharmaceutical Journal, 2015, 50(4): 305-309. DOI: 10.11669/cpj.2015.04.009 | |
| Authors: | LIU Wei ZHANG Wen-juan LIN Li-jun WEI Feng MA Shuang-cheng |
| Affiliation: | 1. National Institutes for Food and Drug Control, Beijing 100050, China; 2. Shenzhen Luohu District Hospital of Traditional Chinese Medicine, Shenzhen 518001, China |
| Abstract: | OBJECTIVE To analyze the quality of crude drug materials and decoction pieces of Fritillariae Cirrhosae Bulbus by the national wide quality surveillance of 72 batches of samples in 2013, and study the suitability of polymerase chain reaction-restriction enzymes length polymorphism (PCR-RFLP) tests. METHODS The samples from different origins were identified and detected according to the standard of Chinese Pharmacopoeia. RESULTS Seventeen batches of samples did not meet the requirements, resulting in a disqualification rate of 25.4%. CONCLUSION Further measures should be taken to improve the quality standard and strengthen the quality surveillance of Fritillariae Cirrhosae Bulbus and other species of Chinese material medica. |
| Keywords: | Fritillariae Cirrhosae Bulbus quality control quality standard |
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