Assessment of malignancy of glioma by positron emission tomography with 18F-fluorodeoxyglucose and single photon emission computed tomography with thallium-201 chloride |
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| Authors: | M. Tamura T. Shibasaki A. Zama H. Kurihara S. Horikoshi N. Ono N. Oriuchi T. Hirano |
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| Affiliation: | (1) Department of Neurosurgery, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi 371, Japan Tel. + 81-272-20-7111 ext. 8511; Fax + 81-272-33-6300, JP;(2) Department Nuclear Medicine, Gunma University School of Medicine, Maebashi, Japan, JP |
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| Abstract: | The histological diagnosis and proliferative potential measured by bromodeoxyuridine (BrdU) labelling index (LI) were corelated with preoperative CT and contrast-enhanced, MRI, 18F-flurodeoxyglucose positron emission tomography (PET) and 201T1 single photon emission computed tomography (SPECT) in 43 patients with various grades of glioma. 201T1 SPECT had slightly higher sensitivity to tumours with BrdU LI N 5 % (showing 10/10) than 18F-FDG PET (7/8 tumours). 18F-FDG PET was better for identifying tumours of BrdU LI < 1 % (13/15) than 201T1 SPECT (13/22). Accumulation of 201T1 in the tumour was slightly different from contrast enhancement on CT and/or MRI, and gave “false-postive” results in some low-grade gliomas. However, 201T1 SPECT, which is available in many hospitals and may cost less, provided useful information to supplement that from CT and MRI. Received: 25 November 1996 Accepted: 8 September 1997 |
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| Keywords: | Glioma grading Bromodeoxyuirdine labelling index 18F-fluorodeoxyglucose Thallium-201 chloride Positron emission tomography Single photon emission computed tomography |
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