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Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice |
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| Authors: | Gregory E Demas Randy J Nelson Bruce K Krueger Paul J Yarowsky |
| Affiliation: | a Behavioral Neuroendocrinology Group, Department of Psychology, and Department of Neuroscience, The Johns Hopkins University, Baltimore, MD 21218, USA b Department of Physiology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA c Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine, Baltimore, MD 21201, USA |
| Abstract: | To evaluate the cognitive phenotype of the segmental trisomy 16 (Ts65Dn) mouse, a model of Down Syndrome (DS, trisomy 21), we assessed spatial working and reference memory using a 12-arm radial maze (RAM). Ts65Dn mice made a greater number of reference memory errors across trials compared to control mice. Both genotypes showed improvement across trials, although improvement was slower in Ts65Dn mice. Ts65Dn mice also made a greater number of working memory errors on the RAM, and in contrast to control mice, did not improve across trials, always performing at near-chance levels. These results provide evidence for both spatial working and reference memory deficits in Ts65Dn mice, characteristics of cognitive dysfunction. |
| Keywords: | Learning Memory Down syndrome Trisomy 16 |
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