| 注射用硫酸阿司米星多剂量给药在健康人体的药代动力学 |
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| 引用本文： | 赵彩芸,吕媛,魏敏吉,张朴,刘燕,肖永红.注射用硫酸阿司米星多剂量给药在健康人体的药代动力学[J].中国临床药理学杂志,2011,27(1):19-23. |
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| 作者姓名： | 赵彩芸 吕媛 魏敏吉 张朴 刘燕 肖永红 |
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| 作者单位： | 北京大学第一医院,临床药理研究所,北京,100034 |
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| 摘 要： | 目的 研究注射用硫酸阿司米星(氨基糖苷类抗生素)多剂量给药在健康人体的药代动力学.方法 10名受试者恒速静脉滴注硫酸阿司米星200 mg,30 min,每日2次,间隔12 h,连续7 d.在第1 d和第7 d分别在不同时间取静脉血,收集尿样,给药第4～6 d采取谷浓度.用柱前衍生化-荧光HPLC法测定血药、尿药浓度.结...
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| 关 键 词： | 硫酸阿司米星 药代动力学 多剂量给药 高效液相色谱法 |
Pharmacokinetics of multiple-dose astromicin sulfate injection in Chinese healthy volunteers |
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| ZHAO Cai-yun,LV Yuan,WEI Min-ji,ZHANG Pu,LIU Yan,XIAO Yong-hong.Pharmacokinetics of multiple-dose astromicin sulfate injection in Chinese healthy volunteers[J].The Chinese Journal of Clinical Pharmacology,2011,27(1):19-23. |
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| Authors: | ZHAO Cai-yun LV Yuan WEI Min-ji ZHANG Pu LIU Yan XIAO Yong-hong |
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| Institution: | ZHAO Cai-yun,LV Yuan,WEI Min-ji,ZHANG PuLIU Yan,XIAO Yong-hong(Institute of Clinical Pharmacology,First Hospital,Peking University,Beijing 100034,China) |
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| Abstract: | Objective To evaluate the pharmacokinetics of multiple dose of astromicin injection in Chinese healthy volunteers.Methods Ten male volunteers were administrated intravenously 200 mg of astromicin within 0.5 h infusion,twice daily for 7 days.The blood and urine samples were collected at day 1 and day 7 respectively.At day 4-6,only collected blood sample before infusion.The concentrations of astromicin were determinated by precolumn derivatization-fluorescence HPLC method.Results The main pharmacokinetic para... |
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| Keywords: | astromicin multiple-dose pharmacokinetics HPLC |
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