| 脑脊液单核细胞内结核抗原检测在结核性脑膜炎早期诊断中的价值 |
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| 引用本文： | 应爱娟,黄金莲,胡智星,陈龙法,程超婵,涂汉明,朱美丽. 脑脊液单核细胞内结核抗原检测在结核性脑膜炎早期诊断中的价值[J]. 全科医学临床与教育, 2011, 9(6): 629-631 |
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| 作者姓名： | 应爱娟 黄金莲 胡智星 陈龙法 程超婵 涂汉明 朱美丽 |
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| 作者单位： | 永康市第一人民医院神经内科,浙江金华,321300 |
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| 摘 要： | 目的探讨脑脊液单核细胞内结核抗原检测在结核性脑膜炎临床诊断中的价值。方法脑脊液样本120例,其中结核性脑膜炎组60例,对照组60例,采用免疫组化法检测脑脊液中单核细胞内的结核抗原,同时进行脑脊液细胞学检查。结果与对照组比较,结脑组中性粒细胞、淋巴样细胞(包括转移淋巴)、激活单核细胞明显升高,差异均有统计学意义(χ2分别=22.76、17.05、4.04、11.76,P均<0.05)。结核性脑膜炎患者脑脊液中单核细胞内存在结核菌素抗原,60例结核性脑膜炎患者中首次检查48例阳性,敏感性为80.00%;对照组有1例阳性,特异性为98.33%,结核性脑膜炎组和对照组多次检测结果敏感性和特异性均较高,差异均有统计学意义(χ2分别=76.19、71.55、35.28,P均<0.05)。结论检测脑脊液中单核细胞内结核抗原可以做为结核性脑膜炎早期诊断的一种重要手段。
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| 关 键 词： | 结核性脑膜炎 脑脊液 结核菌素抗原 |
Tuberculosis antigen detection in cerebrospinal fluid mononuclear cell in early diagnosis of tuberculous meningitis |
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| YING Aijuan,HUANG Jinlian,HU Zhixing,et al.. Tuberculosis antigen detection in cerebrospinal fluid mononuclear cell in early diagnosis of tuberculous meningitis[J]. clinical education of general practice, 2011, 9(6): 629-631 |
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| Authors: | YING Aijuan HUANG Jinlian HU Zhixing et al. |
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| Affiliation: | YING Aijuan,HUANG Jinlian,HU Zhixing,et al.Neurology Department,the First People's Hospital of Yongkang,Yongkang 321300,China |
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| Abstract: | Objective To investigate the value of tuberculosis antigen detection in cerebrospinal fluid mononuclear cells for clinical diagnosis of tuberculous meningitis.Methods A total of 120 cerebrospinal fluid samples,including 60 patients in tuberculous meningitis group(TMG) and 60 patients in the control group(CG) was collected.Tuberculosis antigen in mononuclear cells of cerebrospinal fluid was detected by immunohistochemisty,and cerebrospinal fluid cytology was examined.Results Compared with the control group,t... |
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| Keywords: | tuberculous meningitis cerebrospinal fluid tuberculosis antigens |
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