| 白介素-1和神经生长因子对周围神经再生的影响 |
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| 引用本文： | 刘京升,孙正义,王宏沛,洪光祥. 白介素-1和神经生长因子对周围神经再生的影响[J]. 中国组织工程研究与临床康复, 2002, 6(18): 2696-2697 |
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| 作者姓名： | 刘京升 孙正义 王宏沛 洪光祥 |
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| 作者单位： | 兰州医学院第二附属医院,甘肃兰州,730000 |
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| 摘 要： | 目的采用神经再生室研究白介素-1(IL-1)和神经生长因子(NGF)对周围神经再生的影响。方法将36只SD大鼠随机分为IL-1、NGF和生理盐水3组,制作成坐骨神经再生室模型,术后7、14、30d取材作组织学检查。结果IL-1组和NGF组周围神经再生明显优于生理盐水组,IL-1组和NGF组之间无明显差异。结论IL-1和NGF具有相同的促进周围神经再生的作用。
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| 关 键 词： | 神经再生 神经生长因子 白介素-1 神经再生室 |
| 文章编号： | 1671-5926(2002)18-2696-02 |
| 修稿时间： | 2002-04-08 |
Effect of interleukin-1and NGF on peripheral never regeneration |
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| LI U Jing-sheng,SUN Zheng-yi,WANG H ong-pei,et al.. Effect of interleukin-1and NGF on peripheral never regeneration[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(18): 2696-2697 |
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| Authors: | LI U Jing-sheng SUN Zheng-yi WANG H ong-pei et al. |
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| Affiliation: | LI U Jing-sheng,SUN Zheng-yi,WANG H ong-pei,et al.Second Af-filiated Hospit al,Lanzhou Medical College,Lanzhou 730000,China |
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| Abstract: | Objective To study the effort of interleukin-1(IL-1)and nerve growth factor(NGF)on p eripheral never regeneration after injury.Methods Thirty-six SD rats were div ided randomly into three groups.IL-1were inj ected into the chamber of one ex perim ental group(IL-1),equal quantity of NGF into the chamb er of another experimental group(NGF group),and equal quantity of saline into th e control group(saline group).The specimens were observed histologically.Results The n umber of regeneration never in I L-1group and NGF group were more than that in saline group,but no difference between NGF group and IL-1group.Conclusions IL-1and NGF can enhance the regen-eration of peripheral nerve and stim ulate the proliferation of fibrobla sts,macrophages. |
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| Keywords: | never regeneration nerve growth fa ctors interleukin-1 nerve regeneration chamber |
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