Comparison of hyperpolarized 3He MRI rat lung volume measurement with micro‐computed tomography |
| |
| Authors: | M. Reza Akhavan Sharif Wilfred W. Lam Alexei V. Ouriadov David W. Holdsworth Giles E. Santyr |
| |
| Affiliation: | 1. Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA, USA;2. Imaging Research, Sunnybrook Health Sciences Centre, Toronto, ON, Canada;3. Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada;4. Department of Medical Biophysics, The University of Western Ontario, London, ON, Canada;5. Department of Diagnostic Radiology and Nuclear Medicine, The University of Western Ontario, London, ON, Canada |
| |
| Abstract: | ![]()
In this study, the upper‐limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized 3He‐MR imaging is compared with that determined by micro‐computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norway rats (210–259 g) were ventilated with O2, alternately with 3He, using a computer‐controlled ventilator, and 3D density‐weighted images of the lungs were acquired during a breath hold after six wash‐in breaths of 3He. The rats were then transferred to a micro‐CT scanner, and a similar experimental setup was used to obtain images of the lungs during a breath hold of air with an airway pressure equal to that of the MR imaging breath hold. The upper‐limit and absolute volumes obtained from 3He‐MR and micro‐CT methods were not significantly different (p > 0.05). The good agreement between the lung volumes measured with the two imaging methods suggests that 3He‐MR imaging can be used for quantitative analysis of lung volume changes in longitudinal studies without the exposure to the ionizing radiation which accompanies micro‐CT imaging. Copyright © 2010 John Wiley & Sons, Ltd. |
| |
| Keywords: | hyperpolarized 3He magnetic resonance imaging breath hold rat lung volumes micro‐computed tomography |
|
|
