Feasibility of FAIR imaging for evaluating tumor perfusion |
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| Authors: | Jee‐Hyun Cho MS Gyunggoo Cho PhD Youngkyu Song MS Chulhyun Lee PhD Bum‐Woo Park BS Chang Kyung Lee MS Namkug Kim PhD Sung Bin Park MD Jong Soon Kang PhD Moo Rim Kang PhD Hwan Mook Kim PhD Young Ro Kim PhD Kyoung‐Sik Cho MD Jeong Kon Kim MD |
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| Affiliation: | 1. Division of Magnetic Resonance, Korea Basic Science Institute, 804‐1 Ochang, Cheongwon, Chungbuk, 363‐883, Korea;2. Authors equally contributed to this study;3. Department of Radiology, Research Institute of Radiology, Medical Imaging Laboratory, Asan Medical Center, University of Ulsan College of Medicine, Songpa‐gu, Seoul, Korea;4. Department of Radiology, Ulsan University Hospital, University of Ulsan, Ulsan, Korea;5. Bioevaluation Center, Korean Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea;6. Athinoula A. Martinos Center for Biomedical Imaging, Department ofRadiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA |
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| Abstract: | ![]()
Purpose: To evaluate the feasibility of flow‐sensitive alternating inversion recovery (FAIR) for measuring blood flow in tumor models. Materials and Methods: In eight mice tumor models, FAIR and dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) was performed. The reliability for measuring blood flow on FAIR was evaluated using the coefficient of variation of blood flow on psoas muscle. Three regions of interest (ROIs) were drawn in the peripheral, intermediate, and central portions within each tumor. The location of ROI was the same on FAIR and DCE‐MR images. The correlation between the blood flow on FAIR and perfusion‐related parameters on DCE‐MRI was evaluated using the Pearson correlation coefficient. Results: The coefficient of variation for measuring blood flow was 9.8%. Blood flow on FAIR showed a strong correlation with Kep (r = 0.77), percent relative enhancement (r = 0.73), and percent enhancement ratio (r = 0.81). The mean values of blood flow (mL/100 g/min) (358 vs. 207), Kep (sec?1) (7.46 vs. 1.31), percent relative enhancement (179% vs. 134%), and percent enhancement ratio (42% vs. 26%) were greater in the peripheral portion than in the central portion (P < 0.01). Conclusion: As blood flow measurement on FAIR is reliable and closely related with that on DCE‐MR, FAIR is feasible for measuring tumor blood flow. J. Magn. Reson. Imaging 2010;32:738–744. © 2010 Wiley‐Liss, Inc. |
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| Keywords: | flow‐sensitive alternating inversion recovery arterial spin labeling blood flow angiogenesis magnetic resonance imaging |
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