In vivo sodium imaging of human patellar cartilage with a 3D cones sequence at 3 T and 7 T

Purpose:

To compare signal‐to‐noise ratios (SNRs) and T*₂ maps at 3 T and 7 T using 3D cones from in vivo sodium images of the human knee.

Materials and Methods:

Sodium concentration has been shown to correlate with glycosaminoglycan content of cartilage and is a possible biomarker of osteoarthritis. Using a 3D cones trajectory, 17 subjects were scanned at 3 T and 12 at 7 T using custom‐made sodium‐only and dual‐tuned sodium/proton surface coils, at a standard resolution (1.3 × 1.3 × 4.0 mm³) and a high resolution (1.0 × 1.0 × 2.0 mm³). We measured the SNR of the images and the T*₂ of cartilage at both 3 T and 7 T.

Results:

The average normalized SNR values of standard‐resolution images were 27.1 and 11.3 at 7 T and 3 T. At high resolution, these average SNR values were 16.5 and 7.3. Image quality was sufficient to show spatial variations of sodium content. The average T*₂ of cartilage was measured as 13.2 ± 1.5 msec at 7 T and 15.5 ± 1.3 msec at 3 T.

Conclusion:

We acquired sodium images of patellar cartilage at 3 T and 7 T in under 26 minutes using 3D cones with high resolution and acceptable SNR. The SNR improvement at 7 T over 3 T was within the expected range based on the increase in field strength. The measured T*₂ values were also consistent with previously published values. J. Magn. Reson. Imaging 2010;32:446–451. © 2010 Wiley‐Liss, Inc.