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| 黄药子的肝脏毒性研究 | |
| 引用本文： | 谭兴起,阮金兰,陈海生,王菊英. 黄药子的肝脏毒性研究[J]. 中国中药杂志, 2003, 28(7): 661-663 |
| 作者姓名： | 谭兴起 阮金兰 陈海生 王菊英 |
| 作者单位： | 1. 解放军第九八医院,浙江,湖州,313000 2. 华中科技大学同济医学院,药学院,湖北,武汉,430030 3. 第二军医大学,药学院,上海,200433 |
| 摘 要： | 目的:考察黄药子总甲醇提取物不同极性部位的肝脏毒性。方法:灌胃给药10d后测定大鼠的直接胆红素(direct bilirubin,DBil),谷-丙转氨酶(glutmic-pyruvic transaminase,GPT);称量肝重量并计算肝指数;观察大鼠外观、行为及饮食的变化;对肝脏组织进行光镜及电镜观察。结果:甲醇总提取物及其氯仿部位对大鼠的GPT、肝指数、外观、行为、饮食及肝脏的组织形态有显著的影响。结论:氯仿部位是黄药子甲醇总提取物的肝脏毒性部位。 |
| 关 键 词： | 黄药子 肝脏毒性 |
| 文章编号： | 1001-5302(2003)07-0660-03 |
| 收稿时间： | 2002-10-20 |
| 修稿时间： | 2002-10-20 |
Studies on Liver-toxicity in Rhigoma of Dioscorea bulbifera |
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| TAN Xing-qi;RUAN Jin-lan;CHEN Hai-sheng;WANG Ju-ying. Studies on Liver-toxicity in Rhigoma of Dioscorea bulbifera[J]. China Journal of Chinese Materia Medica, 2003, 28(7): 661-663 | |
| Authors: | TAN Xing-qi RUAN Jin-lan CHEN Hai-sheng WANG Ju-ying |
| Affiliation: | NO. 98 Hospital of PLA, Huzhou 313000, Zhejang, China. tanxq@sohu.com |
| Abstract: | Objective: To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera. Method: The rats were randomized into four groups: control group (20%PVP-water) , T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transarninase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope. Result: T001 and F002 showed significant liver toxicity. Conclusion: The chloroform fraction was the liver-toxic fraction of D. bulbifera . |
| Keywords: | Dioscorea bulbifera liver toxicity |
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