贝那普利对慢性心力衰竭患者临床及血浆脑钠素水平的影响

目的观察贝那普利对慢性心力衰竭（CHF）患者临床及血浆脑钠素水平的影响。方法118例CHF患者随机分为两组：对照组58例患者给予抗心力衰竭的常规治疗。治疗组60例在对照组基础上加用贝那普利2．5mg／d，1周后增加至5～10mg／d。两组均治疗3个月。同时观察临床症状及体征及药物不良反应。两组分别于治疗前及治疗3个月后测定左室射血分数（LVEF）及血浆脑钠素水平。结果治疗3个月后治疗组总有效率显著高于对照组（P〈0．05）；治疗组LVEF较对照组增加更显著（P〈0．01）；治疗组血浆BNP水平较对照组下降更显著（P〈0．01）。结论CHF患者在常规治疗同时加用贝那普利治疗，可以显著降低血浆脑钠素水平，增加LVEF，改善心功能。

The effects of Benazepril on clinical and plasma brain natriuretic peptide levels of patients with chronic heart failure

Objective To observe the effects of benazepril on chronic heart failure （CHF） in patients with clinical and brain natriuretic peptide levels. Methods 118 cases of CHF were randomly divided into 2 groups： control group, 58 cases of heart failure patients given conventional anti-governance. Treatment group, 60 cases in the control group plus benazepril 2. 5 mg/ d, 1 weeks after the increase to 5 - 10 mg/d. 2 groups were treated for 3 months. At the same time, observation of clinical symptoms and signs, and adverse drug reactions. Group 2, respectively, before treatment and treatment in the three months after the determination of left ventricular ejection fraction （LVEF） and plasma levels of brain natriuretic peptide. Results After 3 months treatment group was significantly higher than the efficiency （ P 〈 0.05 ） ; the treatment group than the control group, LVEF increased significantly （P 〈 0.01 ） ; plasma BNP levels of the treatment group than the control group decreased significantly （P 〈 0. 01 ）. Conclusion The conclusions of conventional treatment in patients with CHF at the same time plus benazepril treatment, can significantly reduce the level of plasma brain natriuretic peptide, increased LVEF, improvement in cardiac function.