The effect of sleep deprivation on sleep in rats with suprachiasmatic lesions |
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| Authors: | I Tobler A A Borbély G Groos |
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| Affiliation: | 1. >Dept. of Pharmacology, St. George''s Hospital Medical School, London SW17 UK;1. Division of Neurophysiology and Neuropharmacology, National Institute for Medical Research, Mill Hill, London NW7 1AA U.K. |
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| Abstract: | The adenosine agonist 2-chloroadenosine inhibited the K+-induced release of endogenously synthesized [3H]glutamate but not [3H]GABA from slices of rat dentate gyrus. In contrast, the K+-stimulated release of [3H]glutamate was augmented by the adenosine antagonist theophylline and was further enhanced by the cyclic AMP analogue 8-bromo-cyclic AMP in the presence of theophylline. |
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| Keywords: | hippocampus dentate gyrus neurotransmitter release glutamate GABA 2-chloroadenosine cyclic AMP |
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